Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer

Zhi Yuan Yun, Na Li, Xin Zhang, Huan Zhang, Yue Bu, Yuxiang Sun, Tiemin Liu, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Activated platelets are involved in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are early indexes of platelet activation. The objectives of this study were to investigate the ability of MPV, PDW and carcinoembryonic antigen (CEA) individually or in combination, to distinguish between gastric cancer and gastric ulcer. The study involved 194 patients with gastric cancer, 191 patients with gastric ulcer, and 185 control subjects. Subjects' characteristics and hematologic tests data at initial diagnosis were collected. We found that MPV levels are significantly increased and PDW levels are significantly reduced in patients with gastric ulcer and in control subjects compared with those in gastric cancer. When the area under the curve (AUC) was used to analyze control subjects versus gastric cancer, the combination of PDW and CEA exhibited a significantly larger AUC of 0.939 (0.910-0.961) compared with the combination of MPV and CEA (p = 0.0045). When AUC was used to analyze gastric ulcer versus gastric cancer, PDW alone had the high specificity (98.5%) and high sensitivity (97.4%). In conclusion, combined use of MPV, PDW and CEA can accurately distinguish gastric cancer from gastric ulcer and controls. Further studies in larger samples are warranted.

Original languageEnglish (US)
Pages (from-to)62600-62605
Number of pages6
JournalOncotarget
Volume8
Issue number37
DOIs
StatePublished - Sep 1 2017

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Mean Platelet Volume
Carcinoembryonic Antigen
Stomach Ulcer
Stomach Neoplasms
Blood Platelets
Area Under Curve
Platelet Activation
Hematologic Tests

Keywords

  • Diagnosis
  • Gastric cancer
  • Mean platelet volume
  • Platelet distribution width

ASJC Scopus subject areas

  • Oncology

Cite this

Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer. / Yun, Zhi Yuan; Li, Na; Zhang, Xin; Zhang, Huan; Bu, Yue; Sun, Yuxiang; Liu, Tiemin; Wang, Rui Tao; Yu, Kai Jiang.

In: Oncotarget, Vol. 8, No. 37, 01.09.2017, p. 62600-62605.

Research output: Contribution to journalArticle

Yun, ZY, Li, N, Zhang, X, Zhang, H, Bu, Y, Sun, Y, Liu, T, Wang, RT & Yu, KJ 2017, 'Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer', Oncotarget, vol. 8, no. 37, pp. 62600-62605. https://doi.org/10.18632/oncotarget.15898
Yun, Zhi Yuan ; Li, Na ; Zhang, Xin ; Zhang, Huan ; Bu, Yue ; Sun, Yuxiang ; Liu, Tiemin ; Wang, Rui Tao ; Yu, Kai Jiang. / Mean platelet volume, platelet distribution width and carcinoembryonic antigen to discriminate gastric cancer from gastric ulcer. In: Oncotarget. 2017 ; Vol. 8, No. 37. pp. 62600-62605.
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