Measurement of GABA and contaminants in gray and white matter in human brain in vivo

Changho Choi, Paramjit P. Bhardwaj, Sanjay Kalra, Colin A. Casault, Umme S. Yasmin, Peter S. Allen, Nicholas J. Coupland

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A preliminary study of discrimination between GABA and macromolecules (MMs) in human brain by proton double quantum filtering (DQF) at 3.0T in vivo is presented. GABA-tuned and MM-tuned DQ filters were designed with dual-band 180° radiofrequency (RF) pulses that were tuned for selective refocusing of GABA (3.0 and 1.9 ppm) and putative MM resonances (3.0 and 1.7 ppm), respectively. GABA and putative MM signals were extracted from a combined analysis of the filtered mixture signals and the calculated editing yields. Unexpectedly, the GABA and putative MM signals exhibited a similar doublet linewidth at the optimized TE = 82 ms. Furthermore, substantial MM-tuned DQF signal remained at TE = 148 ms, indicating the presence of a component other than MM. With water segmentation data, the GABA-tuned and MM-tuned DQF measures from the medial prefrontal and left frontal lobes were combined to give the concentrations of GABA and the additional component as 1.1 ± 0.1 and 0.8 ± 0.1 mM (mean ± SD, N = 3) for gray matter (GM) and 0.4 ± 0.1 and 0.7±0.1 mM (N = 3) for white matter (WM), respectively.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalMagnetic Resonance in Medicine
Volume58
Issue number1
DOIs
StatePublished - Jul 2007

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gamma-Aminobutyric Acid
Brain
Frontal Lobe
White Matter
Gray Matter
Protons
Water

Keywords

  • Brain
  • Double-quantum filtering
  • GABA
  • Gray and white matter
  • Macromolecules
  • Proton MRS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Choi, C., Bhardwaj, P. P., Kalra, S., Casault, C. A., Yasmin, U. S., Allen, P. S., & Coupland, N. J. (2007). Measurement of GABA and contaminants in gray and white matter in human brain in vivo. Magnetic Resonance in Medicine, 58(1), 27-33. https://doi.org/10.1002/mrm.21275

Measurement of GABA and contaminants in gray and white matter in human brain in vivo. / Choi, Changho; Bhardwaj, Paramjit P.; Kalra, Sanjay; Casault, Colin A.; Yasmin, Umme S.; Allen, Peter S.; Coupland, Nicholas J.

In: Magnetic Resonance in Medicine, Vol. 58, No. 1, 07.2007, p. 27-33.

Research output: Contribution to journalArticle

Choi, C, Bhardwaj, PP, Kalra, S, Casault, CA, Yasmin, US, Allen, PS & Coupland, NJ 2007, 'Measurement of GABA and contaminants in gray and white matter in human brain in vivo', Magnetic Resonance in Medicine, vol. 58, no. 1, pp. 27-33. https://doi.org/10.1002/mrm.21275
Choi, Changho ; Bhardwaj, Paramjit P. ; Kalra, Sanjay ; Casault, Colin A. ; Yasmin, Umme S. ; Allen, Peter S. ; Coupland, Nicholas J. / Measurement of GABA and contaminants in gray and white matter in human brain in vivo. In: Magnetic Resonance in Medicine. 2007 ; Vol. 58, No. 1. pp. 27-33.
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