Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo

Changho Choi; Deborah Douglas; Halima Hawesa; Ashish Jindal; Charles Storey; Ivan Dimitrov

doi:10.1002/mrm.22125

Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo

Changho Choi, Deborah Douglas, Halima Hawesa, Ashish Jindal, Charles Storey, Ivan Dimitrov

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Measurement of glycine in human frontal brain by an optimized point-resolved spectroscopy sequence at 7 T is reported. Echo time dependencies of the overlapping coupled resonances of myo-inositol, free choline, and threonine were investigated with density matrix simulations, incorporating the slice-selective radiofrequency and gradient pulses. The numerical simulations indicated that the selectivity of the 3.55-ppm glycine singlet is maximized at (TE₁, TE₂) = (101, 51) ms. Phantom experiments indicated that the myo-inositol peak amplitude between 3.5 and 3.6 ppm is reduced by a factor of 30 following the optimized point-resolved spectroscopy, as predicted by the simulation. From LCModel analyses, the glycine concentration in the medial prefrontal cortex in healthy adults was estimated, with a mean Cramér-Rao lower bound of 7 ± 1% (mean ± standard deviation; n = 7), to be 0.8 ± 0.1 mM, with reference to total creatine at 8 mM.

Original language	English (US)
Pages (from-to)	1305-1310
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	62
Issue number	5
DOIs	https://doi.org/10.1002/mrm.22125
State	Published - Nov 2009

Keywords

7 T
Glycine
H-MRS
Human brain
PRESS

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.22125

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title = "Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo",

abstract = "Measurement of glycine in human frontal brain by an optimized point-resolved spectroscopy sequence at 7 T is reported. Echo time dependencies of the overlapping coupled resonances of myo-inositol, free choline, and threonine were investigated with density matrix simulations, incorporating the slice-selective radiofrequency and gradient pulses. The numerical simulations indicated that the selectivity of the 3.55-ppm glycine singlet is maximized at (TE1, TE2) = (101, 51) ms. Phantom experiments indicated that the myo-inositol peak amplitude between 3.5 and 3.6 ppm is reduced by a factor of 30 following the optimized point-resolved spectroscopy, as predicted by the simulation. From LCModel analyses, the glycine concentration in the medial prefrontal cortex in healthy adults was estimated, with a mean Cram{\'e}r-Rao lower bound of 7 ± 1% (mean ± standard deviation; n = 7), to be 0.8 ± 0.1 mM, with reference to total creatine at 8 mM.",

keywords = "7 T, Glycine, H-MRS, Human brain, PRESS",

author = "Changho Choi and Deborah Douglas and Halima Hawesa and Ashish Jindal and Charles Storey and Ivan Dimitrov",

year = "2009",

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doi = "10.1002/mrm.22125",

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T1 - Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo

AU - Choi, Changho

AU - Douglas, Deborah

AU - Hawesa, Halima

AU - Jindal, Ashish

AU - Storey, Charles

AU - Dimitrov, Ivan

PY - 2009/11

Y1 - 2009/11

N2 - Measurement of glycine in human frontal brain by an optimized point-resolved spectroscopy sequence at 7 T is reported. Echo time dependencies of the overlapping coupled resonances of myo-inositol, free choline, and threonine were investigated with density matrix simulations, incorporating the slice-selective radiofrequency and gradient pulses. The numerical simulations indicated that the selectivity of the 3.55-ppm glycine singlet is maximized at (TE1, TE2) = (101, 51) ms. Phantom experiments indicated that the myo-inositol peak amplitude between 3.5 and 3.6 ppm is reduced by a factor of 30 following the optimized point-resolved spectroscopy, as predicted by the simulation. From LCModel analyses, the glycine concentration in the medial prefrontal cortex in healthy adults was estimated, with a mean Cramér-Rao lower bound of 7 ± 1% (mean ± standard deviation; n = 7), to be 0.8 ± 0.1 mM, with reference to total creatine at 8 mM.

AB - Measurement of glycine in human frontal brain by an optimized point-resolved spectroscopy sequence at 7 T is reported. Echo time dependencies of the overlapping coupled resonances of myo-inositol, free choline, and threonine were investigated with density matrix simulations, incorporating the slice-selective radiofrequency and gradient pulses. The numerical simulations indicated that the selectivity of the 3.55-ppm glycine singlet is maximized at (TE1, TE2) = (101, 51) ms. Phantom experiments indicated that the myo-inositol peak amplitude between 3.5 and 3.6 ppm is reduced by a factor of 30 following the optimized point-resolved spectroscopy, as predicted by the simulation. From LCModel analyses, the glycine concentration in the medial prefrontal cortex in healthy adults was estimated, with a mean Cramér-Rao lower bound of 7 ± 1% (mean ± standard deviation; n = 7), to be 0.8 ± 0.1 mM, with reference to total creatine at 8 mM.

KW - 7 T

KW - Glycine

KW - H-MRS

KW - Human brain

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JO - Magnetic resonance in medicine

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Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo

Abstract

Keywords

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