Abstract
To examine the feasibility of measuring the nitric oxide (NO) metabolites nitrate and nitrite in microdialysate samples from the human brain, microdialysis probes were placed in normal appearing cerebral cortex of severely head injured patients in the Neurosurgical Intensive Care Unit at Ben Taub General Hospital. Nitrate/nitrite analysis was performed using NO chemiluminescence. Low micromolar levels of NO metabolites were consistently and easily detected. These levels seen are comparable to levels reported in CSF but tissue tortuosity and probe recovery considerations suggest that the absolute concentrations at the probe site are probably ten fold higher. Microdialysis with measurement of nitric oxide metabolites is technically feasible and may provide valuable insights into both normal neurochemistry and neurochemical derangements in disease.
Original language | English (US) |
---|---|
Pages (from-to) | 343-345 |
Number of pages | 3 |
Journal | Acta Neurochirurgica, Supplement |
Volume | 81 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Head injury
- Microdialysis
- Nitric oxide
ASJC Scopus subject areas
- Surgery
- Clinical Neurology