Measuring fatigue for children with cancer: Development and validation of the pediatric functional assessment of chronic illness therapy-fatigue (pedsFACIT-F)

Jin Shei Lai, David Cella, Mary Jo Kupst, Suzanne Holm, Michael E. Kelly, Rita K. Bode, Stewart Goldman

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Fatigue is a major concern for cancer patients of all ages. The lack of an appropriate assessment tool has impeded our understanding of its prevalence and significance, specifically in the pediatric cancer population. This paper documents the reliability and validity of the pediatric Functional Assessment of Chronic Illness Therapy-Fatigue (pedsFACIT-F) in a comprehensive manner. The 11-item PedsFACIT-F was developed via literature review, feedback from patient/parent/clinician, and a face-to-face consensus meeting. Its reliability and validity were examined on the basis of data from 159 pediatric patients with cancer via classical test theory and Rasch analysis. Results showed that the pedsFACIT-F demonstrated good internal consistency (Cronbach α), acceptable item-total correlations, and met the unidimensionality assumption set by confirmatory factor analysis. All items had acceptable fit statistics in the Rasch analysis and demonstrated stable measurement properties by age, sex, and cancer type. Scores on the pedsFACIT-F significantly discriminated between patients with and without anemia and among patients with different functional status; clinically relevant minimally important differences were estimated accordingly. The pedsFACIT-F was significantly correlated to the PedsQL Multidimensional Fatigue Scale. In conclusion, the pedsFACIT-F demonstrates satisfactory reliability and validity and can be a useful tool in clinical trials and other research.

Original languageEnglish (US)
Pages (from-to)471-479
Number of pages9
JournalJournal of Pediatric Hematology/Oncology
Volume29
Issue number7
DOIs
StatePublished - Jul 1 2007

Fingerprint

Reproducibility of Results
Fatigue
Chronic Disease
Pediatrics
Neoplasms
Therapeutics
Statistical Factor Analysis
Anemia
Clinical Trials
Research
Population

Keywords

  • Cancer-related fatigue
  • Children with cancer
  • PedsFACIT-F
  • Rasch analysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Measuring fatigue for children with cancer : Development and validation of the pediatric functional assessment of chronic illness therapy-fatigue (pedsFACIT-F). / Lai, Jin Shei; Cella, David; Kupst, Mary Jo; Holm, Suzanne; Kelly, Michael E.; Bode, Rita K.; Goldman, Stewart.

In: Journal of Pediatric Hematology/Oncology, Vol. 29, No. 7, 01.07.2007, p. 471-479.

Research output: Contribution to journalArticle

Lai, Jin Shei ; Cella, David ; Kupst, Mary Jo ; Holm, Suzanne ; Kelly, Michael E. ; Bode, Rita K. ; Goldman, Stewart. / Measuring fatigue for children with cancer : Development and validation of the pediatric functional assessment of chronic illness therapy-fatigue (pedsFACIT-F). In: Journal of Pediatric Hematology/Oncology. 2007 ; Vol. 29, No. 7. pp. 471-479.
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