Measuring Health-Related Quality of Life in Children With ESRD: Performance of the Generic and ESRD-Specific Instrument of the Pediatric Quality of Life Inventory (PedsQL)

Stuart L. Goldstein, Nicole Graham, Bradley A. Warady, Mouin Seikaly, Ruth McDonald, Tasha M. Burwinkle, Christine A. Limbers, James W. Varni

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: Minimal data exist to describe health-related quality of life in children with end-stage renal disease (ESRD). Study Design: Cross-sectional study. Setting & Participants: 193 children aged 5 to 18 years with ESRD and 190 parents of children aged 2 to 18 years with ESRD at 4 pediatric nephrology centers across the United States. Outcomes & Measurements: Generic and disease-specific health-related quality of life. The Pediatric Quality of Life Inventory version 4.0 (PedsQL 4.0) Generic Core Scales encompass: (1) Physical Functioning (8 items), (2) Emotional Functioning (5 items), (3) Social Functioning (5 items), and (4) School Functioning (5 items). The PedsQL 3.0 ESRD Module encompasses: (1) General Fatigue (4 items), (2) About My Kidney Disease (5 items), (3) Treatment Problems (4 items), (4) Family and Peer Interaction (3 items), (5) Worry (10 items), (6) Perceived Physical Appearance (3 items), and (7) Communication (5 items). Results: Internal consistency reliability for the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 ESRD Module was acceptable for both parent-proxy report and child self-report, with the exception of 1 parent-proxy report and 3 child self-report scales on the ESRD Module. The PedsQL Generic Core Scales differentiated between healthy children and children with ESRD, supporting discriminant validity. Intercorrelations between the PedsQL Generic Core Scales and the ESRD Module were in the medium to large range, supporting construct validity. A confirmatory factor analysis further supported construct validity of the ESRD Module. Limitations: Test-retest reliability was not conducted, limited generalizability may exist given the age distribution of the children included, and imperfect agreement between child and parent-proxy reports. Conclusions: Results support the feasibility, reliability, and validity of the PedsQL 4.0 Generic Core Scales in children with ESRD and provide initial support for the PedsQL 3.0 ESRD Module, although additional validation testing is warranted.

Original languageEnglish (US)
Pages (from-to)285-297
Number of pages13
JournalAmerican Journal of Kidney Diseases
Volume51
Issue number2
DOIs
StatePublished - Feb 2008

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Chronic Kidney Failure
Quality of Life
Pediatrics
Equipment and Supplies
Proxy
Reproducibility of Results
Self Report
Nephrology
Age Distribution
Kidney Diseases
Statistical Factor Analysis
Fatigue
Cross-Sectional Studies
Parents
Communication

Keywords

  • children
  • end-stage renal disease
  • patient-reported outcomes
  • Pediatric Quality of Life Inventory (PedsQL)

ASJC Scopus subject areas

  • Nephrology

Cite this

Measuring Health-Related Quality of Life in Children With ESRD : Performance of the Generic and ESRD-Specific Instrument of the Pediatric Quality of Life Inventory (PedsQL). / Goldstein, Stuart L.; Graham, Nicole; Warady, Bradley A.; Seikaly, Mouin; McDonald, Ruth; Burwinkle, Tasha M.; Limbers, Christine A.; Varni, James W.

In: American Journal of Kidney Diseases, Vol. 51, No. 2, 02.2008, p. 285-297.

Research output: Contribution to journalArticle

Goldstein, Stuart L. ; Graham, Nicole ; Warady, Bradley A. ; Seikaly, Mouin ; McDonald, Ruth ; Burwinkle, Tasha M. ; Limbers, Christine A. ; Varni, James W. / Measuring Health-Related Quality of Life in Children With ESRD : Performance of the Generic and ESRD-Specific Instrument of the Pediatric Quality of Life Inventory (PedsQL). In: American Journal of Kidney Diseases. 2008 ; Vol. 51, No. 2. pp. 285-297.
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abstract = "Background: Minimal data exist to describe health-related quality of life in children with end-stage renal disease (ESRD). Study Design: Cross-sectional study. Setting & Participants: 193 children aged 5 to 18 years with ESRD and 190 parents of children aged 2 to 18 years with ESRD at 4 pediatric nephrology centers across the United States. Outcomes & Measurements: Generic and disease-specific health-related quality of life. The Pediatric Quality of Life Inventory version 4.0 (PedsQL 4.0) Generic Core Scales encompass: (1) Physical Functioning (8 items), (2) Emotional Functioning (5 items), (3) Social Functioning (5 items), and (4) School Functioning (5 items). The PedsQL 3.0 ESRD Module encompasses: (1) General Fatigue (4 items), (2) About My Kidney Disease (5 items), (3) Treatment Problems (4 items), (4) Family and Peer Interaction (3 items), (5) Worry (10 items), (6) Perceived Physical Appearance (3 items), and (7) Communication (5 items). Results: Internal consistency reliability for the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 ESRD Module was acceptable for both parent-proxy report and child self-report, with the exception of 1 parent-proxy report and 3 child self-report scales on the ESRD Module. The PedsQL Generic Core Scales differentiated between healthy children and children with ESRD, supporting discriminant validity. Intercorrelations between the PedsQL Generic Core Scales and the ESRD Module were in the medium to large range, supporting construct validity. A confirmatory factor analysis further supported construct validity of the ESRD Module. Limitations: Test-retest reliability was not conducted, limited generalizability may exist given the age distribution of the children included, and imperfect agreement between child and parent-proxy reports. Conclusions: Results support the feasibility, reliability, and validity of the PedsQL 4.0 Generic Core Scales in children with ESRD and provide initial support for the PedsQL 3.0 ESRD Module, although additional validation testing is warranted.",
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AU - Warady, Bradley A.

AU - Seikaly, Mouin

AU - McDonald, Ruth

AU - Burwinkle, Tasha M.

AU - Limbers, Christine A.

AU - Varni, James W.

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N2 - Background: Minimal data exist to describe health-related quality of life in children with end-stage renal disease (ESRD). Study Design: Cross-sectional study. Setting & Participants: 193 children aged 5 to 18 years with ESRD and 190 parents of children aged 2 to 18 years with ESRD at 4 pediatric nephrology centers across the United States. Outcomes & Measurements: Generic and disease-specific health-related quality of life. The Pediatric Quality of Life Inventory version 4.0 (PedsQL 4.0) Generic Core Scales encompass: (1) Physical Functioning (8 items), (2) Emotional Functioning (5 items), (3) Social Functioning (5 items), and (4) School Functioning (5 items). The PedsQL 3.0 ESRD Module encompasses: (1) General Fatigue (4 items), (2) About My Kidney Disease (5 items), (3) Treatment Problems (4 items), (4) Family and Peer Interaction (3 items), (5) Worry (10 items), (6) Perceived Physical Appearance (3 items), and (7) Communication (5 items). Results: Internal consistency reliability for the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 ESRD Module was acceptable for both parent-proxy report and child self-report, with the exception of 1 parent-proxy report and 3 child self-report scales on the ESRD Module. The PedsQL Generic Core Scales differentiated between healthy children and children with ESRD, supporting discriminant validity. Intercorrelations between the PedsQL Generic Core Scales and the ESRD Module were in the medium to large range, supporting construct validity. A confirmatory factor analysis further supported construct validity of the ESRD Module. Limitations: Test-retest reliability was not conducted, limited generalizability may exist given the age distribution of the children included, and imperfect agreement between child and parent-proxy reports. Conclusions: Results support the feasibility, reliability, and validity of the PedsQL 4.0 Generic Core Scales in children with ESRD and provide initial support for the PedsQL 3.0 ESRD Module, although additional validation testing is warranted.

AB - Background: Minimal data exist to describe health-related quality of life in children with end-stage renal disease (ESRD). Study Design: Cross-sectional study. Setting & Participants: 193 children aged 5 to 18 years with ESRD and 190 parents of children aged 2 to 18 years with ESRD at 4 pediatric nephrology centers across the United States. Outcomes & Measurements: Generic and disease-specific health-related quality of life. The Pediatric Quality of Life Inventory version 4.0 (PedsQL 4.0) Generic Core Scales encompass: (1) Physical Functioning (8 items), (2) Emotional Functioning (5 items), (3) Social Functioning (5 items), and (4) School Functioning (5 items). The PedsQL 3.0 ESRD Module encompasses: (1) General Fatigue (4 items), (2) About My Kidney Disease (5 items), (3) Treatment Problems (4 items), (4) Family and Peer Interaction (3 items), (5) Worry (10 items), (6) Perceived Physical Appearance (3 items), and (7) Communication (5 items). Results: Internal consistency reliability for the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 ESRD Module was acceptable for both parent-proxy report and child self-report, with the exception of 1 parent-proxy report and 3 child self-report scales on the ESRD Module. The PedsQL Generic Core Scales differentiated between healthy children and children with ESRD, supporting discriminant validity. Intercorrelations between the PedsQL Generic Core Scales and the ESRD Module were in the medium to large range, supporting construct validity. A confirmatory factor analysis further supported construct validity of the ESRD Module. Limitations: Test-retest reliability was not conducted, limited generalizability may exist given the age distribution of the children included, and imperfect agreement between child and parent-proxy reports. Conclusions: Results support the feasibility, reliability, and validity of the PedsQL 4.0 Generic Core Scales in children with ESRD and provide initial support for the PedsQL 3.0 ESRD Module, although additional validation testing is warranted.

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