Measuring medication adherence in pediatric cancer: An approach to validation

Jennifer M. Rohan, Tsuyoshi Fukuda, Melissa A. Alderfer, Crista Wetherington Donewar, Linda Ewing, Ernest R. Katz, Anna C. Muriel, Alexander A. Vinks, Dennis Drotar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective This study described the prospective relationship between pharmacological and behavioral measures of 6-mercaptopurine (6MP)medication adherence in amultisite cohort of pediatric patients diagnosed with cancer (N=139). Methods Pharmacological measures (i.e., metabolite concentrations) assessed 6MP intake. Behavioral measures (e.g., electronic monitoring) described adherence patterns over time. Results Three metabolite profiles were identified across 15 months: one group demonstrated low levels of both metabolites (40.8%) consistent with nonadherence and/or suboptimal therapy; two other groups demonstrated metabolite clusters indicative of adequate adherence (59.2%). Those patients whose metabolite profile demonstrated low levels of both metabolites had consistently lower behavioral adherence rates. Conclusions To our knowledge, thiswas the first study to prospectively validate a pharmacological measure of medication adherence with a behavioral adherence measure in a relatively large sample of pediatric patients with cancer. Using multiple methods of adherencemeasurement could informclinical care and target patients in need of intervention.

Original languageEnglish (US)
Pages (from-to)232-244
Number of pages13
JournalJournal of Pediatric Psychology
Volume42
Issue number2
DOIs
StatePublished - 2017

Fingerprint

Medication Adherence
6-Mercaptopurine
Pharmacology
Pediatrics
Neoplasms
Patient Care
Prospective Studies
Therapeutics

Keywords

  • Adherence
  • Cancer
  • Metabolites
  • Metabolites
  • Pediatrics
  • Pharmacology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)
  • Developmental and Educational Psychology

Cite this

Rohan, J. M., Fukuda, T., Alderfer, M. A., Donewar, C. W., Ewing, L., Katz, E. R., ... Drotar, D. (2017). Measuring medication adherence in pediatric cancer: An approach to validation. Journal of Pediatric Psychology, 42(2), 232-244. https://doi.org/10.1093/jpepsy/jsw039

Measuring medication adherence in pediatric cancer : An approach to validation. / Rohan, Jennifer M.; Fukuda, Tsuyoshi; Alderfer, Melissa A.; Donewar, Crista Wetherington; Ewing, Linda; Katz, Ernest R.; Muriel, Anna C.; Vinks, Alexander A.; Drotar, Dennis.

In: Journal of Pediatric Psychology, Vol. 42, No. 2, 2017, p. 232-244.

Research output: Contribution to journalArticle

Rohan, JM, Fukuda, T, Alderfer, MA, Donewar, CW, Ewing, L, Katz, ER, Muriel, AC, Vinks, AA & Drotar, D 2017, 'Measuring medication adherence in pediatric cancer: An approach to validation', Journal of Pediatric Psychology, vol. 42, no. 2, pp. 232-244. https://doi.org/10.1093/jpepsy/jsw039
Rohan, Jennifer M. ; Fukuda, Tsuyoshi ; Alderfer, Melissa A. ; Donewar, Crista Wetherington ; Ewing, Linda ; Katz, Ernest R. ; Muriel, Anna C. ; Vinks, Alexander A. ; Drotar, Dennis. / Measuring medication adherence in pediatric cancer : An approach to validation. In: Journal of Pediatric Psychology. 2017 ; Vol. 42, No. 2. pp. 232-244.
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