Mechanical properties and in vitro degradation of bioresorbable fibers and expandable fiber-based stents

Meital Zilberman, Kevin D. Nelson, Robert C. Eberhart

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Bioresorbable polymeric support devices (stents) are being developed in order to improve the biocompatibility and drug reservoir capacity of metal stents, as well as to offer a temporary alternative to permanent metallic stents. These temporary devices may be utilized for coronary, urethral, tracheal, and other applications. The present study focuses on the mechanical properties of bioresorbable fibers as well as stents developed from these fibers. Fibers made of poly(L-lactide) (PLLA), polydioxanone (PDS), and poly(glycolide-co-ε-caprolactone) (PGACL) were studied in vitro. These fibers combine a relatively high initial strength and modulus together with sufficient ductility and flexibility, and were therefore chosen for use in stents. The effect of degradation on the tensile mechanical properties and morphology of these fibers was examined. The expandable stents developed from these fibers demonstrated excellent initial radial compression strength. The PLLA stents exhibited excellent in vitro degradation resistance and can therefore support body conduits such as blood vessels for prolonged periods of time. PDS and PGACL stents can afford good support for 5 and 2 weeks, respectively, and can therefore be utilized for short-term applications. The degradation resistance of the stents correlates with the profile of mechanical property deterioration of the corresponding bioresorbable fibers.

Original languageEnglish (US)
Pages (from-to)792-799
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume74
Issue number2
DOIs
Publication statusPublished - Aug 2005

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Keywords

  • Bioresorbable
  • Mechanical properties
  • Poly(L-lactic acid)
  • Polydioxanone
  • Stents

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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