Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

Veronique Chauvet, Xin Tian, Herve Husson, David H. Grimm, Tong Wang, Thomas Hieseberger, Peter Igarashi, Anton M. Bennett, Oxana Ibraghimov-Beskrovnaya, Stefan Somlo, Michael J. Caplan

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a proteolytic cleavage that releases its C-terminal tail (CTT), which enters the nucleus and initiates signaling processes. The cleavage occurs in vivo in association with alterations in mechanical stimuli. Polycystin-2, the product of the second gene mutated in ADPKD, modulates the signaling properties of the polycystin-1 CTT. These data reveal a novel pathway by which polycystin-1 transmits messages directly to the nucleus.

Original languageEnglish (US)
Pages (from-to)1433-1443
Number of pages11
JournalJournal of Clinical Investigation
Volume114
Issue number10
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Medicine(all)

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