Mechanism causing vitamin E deficiency during chronic childhood cholestasis

R. J. Sokol, J. E. Heubi, S. Iannaccone, K. E. Bove, W. F. Balistreri

Research output: Contribution to journalArticle

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Abstract

In order to characterize the mechanism(s) causing vitamin E deficiency during chronic childhood cholestasis, we studied 6 vitamin E-deficient cholestatic children with clinical evidence of neurologic dysfunction (group A), 4 vitamin E-sufficient cholestatic children and young adults with normal neurologic status (group B), and 6 vitamin E-sufficient noncholestatic children (group C). Intestinal absorption of dl-α-tocopherol (assessed by an oral tolerance test) was markedly impaired (p < 0.001) in group A compared with groups B and C, which did not differ from each other. Intraluminal total bile acid concentrations were markedly depressed in group A compared with age-matched controls (0.50 vs. 7.00 mM, p < 0.001), whereas concentratons were low normal in group B. Intramuscular dl-α-tocopherol was well absorbed in 4 group A subjects and corrected abnormal hydrogen peroxide hemolysis. Our data suggest that low intraluminal bile acid concentrations result in malabsorption and deficiency of vitamin E in children with prolonged, severe cholestasis. Intact plasma transport and tissue uptake of vitamin E during cholestasis suggest that intramuscular vitamin E should be utilized for prevention and therapy of the neurologic abnormalities caused by vitamin E deficiency.

Original languageEnglish (US)
Pages (from-to)1172-1182
Number of pages11
JournalGastroenterology
Volume85
Issue number5
StatePublished - 1983

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Vitamin E Deficiency
Cholestasis
Vitamin E
Tocopherols
Bile Acids and Salts
Nervous System Malformations
Intestinal Absorption
Neurologic Manifestations
Hemolysis
Hydrogen Peroxide
Nervous System
Young Adult

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sokol, R. J., Heubi, J. E., Iannaccone, S., Bove, K. E., & Balistreri, W. F. (1983). Mechanism causing vitamin E deficiency during chronic childhood cholestasis. Gastroenterology, 85(5), 1172-1182.

Mechanism causing vitamin E deficiency during chronic childhood cholestasis. / Sokol, R. J.; Heubi, J. E.; Iannaccone, S.; Bove, K. E.; Balistreri, W. F.

In: Gastroenterology, Vol. 85, No. 5, 1983, p. 1172-1182.

Research output: Contribution to journalArticle

Sokol, RJ, Heubi, JE, Iannaccone, S, Bove, KE & Balistreri, WF 1983, 'Mechanism causing vitamin E deficiency during chronic childhood cholestasis', Gastroenterology, vol. 85, no. 5, pp. 1172-1182.
Sokol, R. J. ; Heubi, J. E. ; Iannaccone, S. ; Bove, K. E. ; Balistreri, W. F. / Mechanism causing vitamin E deficiency during chronic childhood cholestasis. In: Gastroenterology. 1983 ; Vol. 85, No. 5. pp. 1172-1182.
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