Mechanisms and functional role of intracellular pH regulation in hepatocytes.

S. D. Lidofsky, J. G. Fitz, B. F. Scharschmidt

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Intracellular pH influences and is influenced by a diverse array of hepatocellular processes. It is regulated by the concerted action of three plasma membrane H+/HCO3- transporters that serve to buffer against both acidic (Na+/H+ exchange, Na+/HCO3- cotransport) and basic (Cl-/HCO3- exchange) metabolic challenges. The responsiveness of hepatocytes to these challenges is augmented by a regulatory interplay between pH-mediated changes in Vm and electrogenic Na+/HCO3- cotransport to maintain pHi and Vm within a range optimized to serve liver function. The cost is expenditure of metabolic energy to sustain increased activity of the Na+/K+ pump. The benefit is a dynamic servomechanism well-suited to the metabolic demands of hepatocytes, which may be found in future studies to be employed in other metabolically active epithelia as well.

Original languageEnglish (US)
Pages (from-to)69-83
Number of pages15
JournalProgress in Liver Diseases
Volume11
StatePublished - 1993

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Hepatocytes
Energy Metabolism
Buffers
Epithelium
Cell Membrane
Costs and Cost Analysis
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

Mechanisms and functional role of intracellular pH regulation in hepatocytes. / Lidofsky, S. D.; Fitz, J. G.; Scharschmidt, B. F.

In: Progress in Liver Diseases, Vol. 11, 1993, p. 69-83.

Research output: Contribution to journalArticle

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