Mechanisms and functions of DNA mismatch repair

Research output: Contribution to journalReview article

554 Citations (Scopus)

Abstract

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous recombination and was recently shown to play a role in DNA damage signaling in eukaryotic cells. Escherichia coli MutS and MutL and their eukaryotic homologs, MutSα and MutLα, respectively, are key players in MMR-associated genome maintenance. Many other protein components that participate in various DNA metabolic pathways, such as PCNA and RPA, are also essential for MMR. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including hereditary non-polyposis colorectal cancer, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.

Original languageEnglish (US)
Pages (from-to)85-98
Number of pages14
JournalCell Research
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

DNA Mismatch Repair
Genomic Instability
Genetic Recombination
Proliferating Cell Nuclear Antigen
Meiosis
Eukaryotic Cells
Metabolic Networks and Pathways
DNA Replication
Infertility
DNA Damage
Colorectal Neoplasms
Maintenance
Genome
Escherichia coli
DNA
Neoplasms
Proteins

Keywords

  • Cancer
  • Microsatellite instability
  • MutL
  • MutS

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Mechanisms and functions of DNA mismatch repair. / Li, Guo Min.

In: Cell Research, Vol. 18, No. 1, 01.01.2008, p. 85-98.

Research output: Contribution to journalReview article

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