Mechanisms and mediators of inflammation: Potential models for skin rejection and targeted therapy in vascularized composite allotransplantation

Theresa Hautz, Dolores Wolfram, Johanna Grahammer, Ravi Starzl, Christoph Krapf, Johann Pratschke, W. P Andrew Lee, Gerald Brandacher, Stefan Schneeberger

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Vascularized composite allotransplantation (VCA) is an effective treatment option for patients suffering from limb loss or severe disfigurement. However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft survival. To widen the scope of this quality-of-life improving procedure minimization of immunosuppression in order to limit risks and side effects is needed. In some aspects, the molecular mechanisms and dynamics of skin allograft rejection seem similar to inflammatory skin conditions. T cells are key players in skin rejection and are recruited to the skin via activation of adhesion molecules, cytokines, and chemokines. Blocking these molecules has not only shown success in the treatment of inflammatory dermatoses, but also prolonged graft survival in various models of solid organ transplantation. In addition to T cell recruitment, ectopic lymphoid structures within the allograft associated with chronic rejection in solid organ transplantation might contribute to the strong alloimmune response towards the skin. Selectively targeting the molecules involved offers exciting novel therapeutic options in the prevention and treatment of skin rejection after VCA.

Original languageEnglish (US)
Article number757310
JournalClinical and Developmental Immunology
Volume2012
DOIs
StatePublished - Oct 17 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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