Mechanisms of androgen receptor activation in castration-resistant prostate cancer

Nima Sharifi

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Systemic treatment of advanced prostate cancer is initiated with androgen deprivation therapy by gonadal testosterone depletion. Response durations are variable and tumors nearly always become resistant as castration-resistant prostate cancer (CRPC), which is driven, at least in part, by a continued dependenceonthe androgen receptor (AR). The proposed mechanisms that underlieAR function in this clinical setting are quite varied. These include intratumoral synthesis of androgens from inactive precursors, increased AR expression, AR activation through tyrosine kinase-dependent signaling, alterations in steroid receptor coactivators, and expression of a truncated AR with constitutive activity. Various pharmacologic interventions have clinically validated some of these mechanisms, such as those that require the AR ligand-binding domain. Clinical studies have failed to validate other mechanisms, and additional mechanisms have yet to be tested in patients with CRPC. Here, we review the mechanisms that elicit AR activity in CRPC, with a particular focus on recent developments.

Original languageEnglish (US)
Pages (from-to)4010-4017
Number of pages8
JournalEndocrinology
Volume154
Issue number11
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Endocrinology

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