Mechanisms of bile acid and fatty acid absorption across the unstirred water layer and brush border of the intestine

J. M. Dietschy

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)

Abstract

The role of the bile acid micelle in enhancing fat absorption must be re defined. The fact that the presence of a micellar phase increases fatty acid and steroid uptake in the intestine derives from the fact that the rate limiting step to uptake of these lipids is the unstirred water layer. The bile acid micelle overcomes this resistance by delivering a large mass of lipid across this rate limiting diffusion barrier so that a maximum concentration of fatty acid monomer can be maintained against the lipid cell membrane. The actual act of absorption then takes place by passive diffusion of the fatty acid across the epithelial cell brush border at a rate determined by the concentration of fatty acid monomer in equilibrium with the micelle and the appropriate permeability coefficient.

Original languageEnglish (US)
Title of host publicationHELV.MED.ACTA
Pages89-102
Number of pages14
Volume37
Edition2-3
StatePublished - 1973

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Microvilli
Bile Acids and Salts
Intestines
Micelles
Fatty Acids
Water
Lipids
Membrane Lipids
Permeability
Epithelial Cells
Fats
Steroids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanisms of bile acid and fatty acid absorption across the unstirred water layer and brush border of the intestine. / Dietschy, J. M.

HELV.MED.ACTA. Vol. 37 2-3. ed. 1973. p. 89-102.

Research output: Chapter in Book/Report/Conference proceedingChapter

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