Mechanisms of bone disease in HIV and hepatitis C virus

impact of bone turnover, tenofovir exposure, sex steroids and severity of liver disease

Roger Bedimo, James Cutrell, Song Zhang, Henning Drechsler, Ang Gao, Geri Brown, Irfan Farukhi, Rosinda Castanon, Pablo Tebas, Naim M. Maalouf

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE:: Both HIV and hepatitis C virus (HCV) infections are associated with higher osteoporotic fracture risk. Increased bone turnover, liver fibrosis, tenofovir (TDF) use or hormonal imbalances are possible underlying mechanisms. DESIGN:: This prospective, cross-sectional study assessed 298 male volunteers with either virologically suppressed HIV or untreated HCV mono-infections, HIV/HCV co-infection and noninfected controls. METHODOLOGY:: Study participants underwent bone mineral density (BMD) by dual-energy x-ray absorptiometry and measurement of bone turnover markers [BTM: C-telopeptide (CTX) and osteocalcin (OC)], insulin-like growth factor-1 (IGF-1), the sex steroids testosterone (T) and estradiol (E2), and the aspartate aminotransferase-to-platelet ratio index (APRI). Impact of HIV and HCV status on BMD was evaluated in multivariate models adjusting for APRI score, BTM, TDF exposure, IGF-1, and sex steroids. RESULTS:: HIV and HCV status independently predicted lower BMD, controlling for age, race, BMI, and smoking (P?=?0.017 and P?=?0.010 respectively), whereas APRI did not (P?=?0.84). HIV was associated with increased bone resorption (CTX: P?

Original languageEnglish (US)
JournalAIDS
DOIs
StateAccepted/In press - Nov 10 2015

Fingerprint

Tenofovir
Bone Remodeling
Bone Diseases
Hepacivirus
Liver Diseases
Steroids
HIV
Virus Diseases
Bone Density
Blood Platelets
Somatomedins
Transaminases
Osteoporotic Fractures
Osteocalcin
Bone Resorption
Infection Control
Aspartate Aminotransferases
Coinfection
Liver Cirrhosis
Testosterone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

@article{3060aae8328f4fbca8749ea16050ca2b,
title = "Mechanisms of bone disease in HIV and hepatitis C virus: impact of bone turnover, tenofovir exposure, sex steroids and severity of liver disease",
abstract = "OBJECTIVE:: Both HIV and hepatitis C virus (HCV) infections are associated with higher osteoporotic fracture risk. Increased bone turnover, liver fibrosis, tenofovir (TDF) use or hormonal imbalances are possible underlying mechanisms. DESIGN:: This prospective, cross-sectional study assessed 298 male volunteers with either virologically suppressed HIV or untreated HCV mono-infections, HIV/HCV co-infection and noninfected controls. METHODOLOGY:: Study participants underwent bone mineral density (BMD) by dual-energy x-ray absorptiometry and measurement of bone turnover markers [BTM: C-telopeptide (CTX) and osteocalcin (OC)], insulin-like growth factor-1 (IGF-1), the sex steroids testosterone (T) and estradiol (E2), and the aspartate aminotransferase-to-platelet ratio index (APRI). Impact of HIV and HCV status on BMD was evaluated in multivariate models adjusting for APRI score, BTM, TDF exposure, IGF-1, and sex steroids. RESULTS:: HIV and HCV status independently predicted lower BMD, controlling for age, race, BMI, and smoking (P?=?0.017 and P?=?0.010 respectively), whereas APRI did not (P?=?0.84). HIV was associated with increased bone resorption (CTX: P?",
author = "Roger Bedimo and James Cutrell and Song Zhang and Henning Drechsler and Ang Gao and Geri Brown and Irfan Farukhi and Rosinda Castanon and Pablo Tebas and Maalouf, {Naim M.}",
year = "2015",
month = "11",
day = "10",
doi = "10.1097/QAD.0000000000000952",
language = "English (US)",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Mechanisms of bone disease in HIV and hepatitis C virus

T2 - impact of bone turnover, tenofovir exposure, sex steroids and severity of liver disease

AU - Bedimo, Roger

AU - Cutrell, James

AU - Zhang, Song

AU - Drechsler, Henning

AU - Gao, Ang

AU - Brown, Geri

AU - Farukhi, Irfan

AU - Castanon, Rosinda

AU - Tebas, Pablo

AU - Maalouf, Naim M.

PY - 2015/11/10

Y1 - 2015/11/10

N2 - OBJECTIVE:: Both HIV and hepatitis C virus (HCV) infections are associated with higher osteoporotic fracture risk. Increased bone turnover, liver fibrosis, tenofovir (TDF) use or hormonal imbalances are possible underlying mechanisms. DESIGN:: This prospective, cross-sectional study assessed 298 male volunteers with either virologically suppressed HIV or untreated HCV mono-infections, HIV/HCV co-infection and noninfected controls. METHODOLOGY:: Study participants underwent bone mineral density (BMD) by dual-energy x-ray absorptiometry and measurement of bone turnover markers [BTM: C-telopeptide (CTX) and osteocalcin (OC)], insulin-like growth factor-1 (IGF-1), the sex steroids testosterone (T) and estradiol (E2), and the aspartate aminotransferase-to-platelet ratio index (APRI). Impact of HIV and HCV status on BMD was evaluated in multivariate models adjusting for APRI score, BTM, TDF exposure, IGF-1, and sex steroids. RESULTS:: HIV and HCV status independently predicted lower BMD, controlling for age, race, BMI, and smoking (P?=?0.017 and P?=?0.010 respectively), whereas APRI did not (P?=?0.84). HIV was associated with increased bone resorption (CTX: P?

AB - OBJECTIVE:: Both HIV and hepatitis C virus (HCV) infections are associated with higher osteoporotic fracture risk. Increased bone turnover, liver fibrosis, tenofovir (TDF) use or hormonal imbalances are possible underlying mechanisms. DESIGN:: This prospective, cross-sectional study assessed 298 male volunteers with either virologically suppressed HIV or untreated HCV mono-infections, HIV/HCV co-infection and noninfected controls. METHODOLOGY:: Study participants underwent bone mineral density (BMD) by dual-energy x-ray absorptiometry and measurement of bone turnover markers [BTM: C-telopeptide (CTX) and osteocalcin (OC)], insulin-like growth factor-1 (IGF-1), the sex steroids testosterone (T) and estradiol (E2), and the aspartate aminotransferase-to-platelet ratio index (APRI). Impact of HIV and HCV status on BMD was evaluated in multivariate models adjusting for APRI score, BTM, TDF exposure, IGF-1, and sex steroids. RESULTS:: HIV and HCV status independently predicted lower BMD, controlling for age, race, BMI, and smoking (P?=?0.017 and P?=?0.010 respectively), whereas APRI did not (P?=?0.84). HIV was associated with increased bone resorption (CTX: P?

UR - http://www.scopus.com/inward/record.url?scp=84946593398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946593398&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000000952

DO - 10.1097/QAD.0000000000000952

M3 - Article

JO - AIDS

JF - AIDS

SN - 0269-9370

ER -