Mechanisms of increase in plasma triacylglycerol concentrations as a result of high carbohydrate intakes in patients with non-insulin-dependent diabetes mellitus

Barbara Blades, Abhimanyu Garg

Research output: Contribution to journalArticle

49 Scopus citations


To determine the mechanisms of increase in plasma triacylglycerol concentrations after high dietary intakes of carbohydrates, 10 men with non- insulin-dependent diabetes mellitus (NIDDM) were fed an isoenergetic high- carbohydrate diet (55% of energy as carbohydrate and 30% as fat) and a high- monounsaturated-fat diet (45% of energy as fat and 40% as carbohydrates) for 6 wk in a randomized, crossover manner. The high carbohydrate diet raised fasting plasma triacylglycerol concentrations by 26% (P = 0.007) but did not affect postheparin lipoprotein lipase (P = 0.2) or hepatic lipase activities (P = 0.9). The oral-fat-tolerance test labeled with retinyl palmitate also revealed no differences in postprandial plasma triacylglycerol (P = 0.37) or retinyl palmitate clearances (P = 0.34) between the two diets. We conclude that the increase in plasma triacylglycerol concentrations with high- carbohydrate diets in men with NIDDM is not due to reduced lipolysis or diminished postprandial clearance of triacylglycerol-rich lipoproteins but is primarily due to increased hepatic secretion of very-low-density- lipoprotein, triacylglycerols.

Original languageEnglish (US)
Pages (from-to)996-1002
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number5
Publication statusPublished - Nov 1995



  • chylomicrons
  • Dietary carbohydrates
  • hepatic lipase
  • lipoprotein lipase
  • lipoproteins
  • monounsaturated fatty acids
  • noninsulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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