Mechanisms of Neonatal Heart Regeneration

Alisson C. Cardoso, Ana Helena M. Pereira, Hesham A. Sadek

Research output: Contribution to journalReview article

Abstract

Purpose of Review: This review provides an overview of the molecular mechanisms underpinning the cardiac regenerative capacity during the neonatal period and the potential targets for developing novel therapies to restore myocardial loss. Recent Findings: We present recent advances in the understanding of the molecular mechanisms of neonatal cardiac regeneration and the implications for the development of new cardiac regenerative therapies. During the early postnatal period, several cell types and pathways are involved in cardiomyocyte proliferation including immune response, nerve signaling, extracellular matrix, mitochondria substrate utilization, gene expression, miRNAs, and cell cycle progression. Summary: The early neonatal mammalian heart has remarkable regenerative capacity, which is mediated by proliferation of endogenous cardiomyocytes, and is lost when cardiomyocytes stop dividing shortly after birth. A wide array of mechanisms that regulate this regenerative process have been proposed.

Original languageEnglish (US)
Article number33
JournalCurrent Cardiology Reports
Volume22
Issue number5
DOIs
StatePublished - May 1 2020

Keywords

  • Cell cycle
  • Heart regeneration
  • Hippo
  • MEIS1
  • Metabolism
  • miRNA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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