Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

Syamal K. Datta, Chandra Mohan, Ami Desai-Mehta

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A major step towards understanding the basic mechanism of systemic lupus erythematosus (SLE), the prototypic autoimmune disease that develops spontaneously, has been the identification of nucleosomes as a primary immunogen in this disease. The production of pathogenic autoantibodies in SLE results from an MHC clas-II-restricted, cognate interaction between select populations of T helper cells and B cells that are specific for nucleosomal components. These observations pave the way for specific immunotherapy that blocks this pathogenic T and B cell interaction.

Original languageEnglish (US)
Pages (from-to)132-147
Number of pages16
JournalImmunologic Research
Volume14
Issue number2
DOIs
StatePublished - Jun 1995

Keywords

  • Anti-DNA autoantibodies
  • Autoimmune T cell receptors
  • CD40
  • CD40-ligand
  • Immunotherapy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy'. Together they form a unique fingerprint.

Cite this