Mechanisms regulating regional cerebral activation during dynamic handgrip in humans

J. W. Williamson, D. B. Friedman, J. H. Mitchell, N. H. Secher, L. Friberg

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Dynamic hand movement increases regional cerebral blood flow (rCBF) of the contralateral motor sensory cortex (MS1). This increase is eliminated by regional anesthesia of the working arm, indicating the importance of afferent neural input. The purpose of this study was to determine the specific type of afferent input required for this cerebral activation. The rCBF was measured at +5.0 and +9.0 cm above the orbitomeatal (OM) plane in 13 subjects during 1) rest; 2) dynamic left-hand contractions; 3) postcontraction ischemia (metaboreceptor afferents); and 4) biceps brachii tendon vibration (muscle spindles). The rCBF increased only during dynamic hand contraction; contralateral MS1 (OM +9) by 15% to 64 ± 8.6 ml · 100g-1 · min-1 (P < 0.05); supplementary motor area (OM +9) by 11% to 69 ± 9.8 ml · 100 g-1 · min-1 (P < 0.05); and there were also bilateral increases at MS2 (OM +5) [by 16% to 64 ± 8.6 ml · 100 g-1 · min-1 (P < 0.05)]. These findings suggest that the rCBF increase during dynamic hand contraction does not require neural input from muscle spindles or metabolically sensitive nerve fibers, although the involvement of mechanoreceptors (group III or Ib) cannot be excluded.

Original languageEnglish (US)
Pages (from-to)1884-1890
Number of pages7
JournalJournal of Applied Physiology
Volume81
Issue number5
StatePublished - Nov 1996

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Hand
Muscle Spindles
Mechanoreceptors
Conduction Anesthesia
Motor Cortex
Vibration
Nerve Fibers
Tendons
Arm
Ischemia

Keywords

  • Xe inhalation
  • exercise
  • muscle ischemia
  • single-photon-emission computerized tomography
  • tendon vibration

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Mechanisms regulating regional cerebral activation during dynamic handgrip in humans. / Williamson, J. W.; Friedman, D. B.; Mitchell, J. H.; Secher, N. H.; Friberg, L.

In: Journal of Applied Physiology, Vol. 81, No. 5, 11.1996, p. 1884-1890.

Research output: Contribution to journalArticle

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