Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension

V. S. Markin; V. Gh Shlyonsky; S. A. Simon; D. J. Benos; I. I. Ismailov

doi:10.1134/S0006350906060078

Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension

V. S. Markin, V. Gh Shlyonsky, S. A. Simon, D. J. Benos, I. I. Ismailov

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity that was proportional to the square of membrane radius, but could not be accounted for by the increase in membrane surface area, or by recruitment of new channels. Extrapolated to biological membranes, these observations may suggest that the permeability of ion channels can be influenced simply by changing shape of the membrane, with or without stretching.

Original language	English (US)
Pages (from-to)	892-895
Number of pages	4
Journal	Biophysics
Volume	51
Issue number	6
DOIs	https://doi.org/10.1134/S0006350906060078
State	Published - Dec 2006

Keywords

Bilayer lipid membranes
Gramicidin A
Ion channels

ASJC Scopus subject areas

Biophysics

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10.1134/S0006350906060078

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title = "Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension",

abstract = "Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity that was proportional to the square of membrane radius, but could not be accounted for by the increase in membrane surface area, or by recruitment of new channels. Extrapolated to biological membranes, these observations may suggest that the permeability of ion channels can be influenced simply by changing shape of the membrane, with or without stretching.",

keywords = "Bilayer lipid membranes, Gramicidin A, Ion channels",

author = "Markin, {V. S.} and Shlyonsky, {V. Gh} and Simon, {S. A.} and Benos, {D. J.} and Ismailov, {I. I.}",

note = "Funding Information: ACKNOWLEDGMENTS Supported by the National Institute of Health grants DK37206 (DJB), GM-27278 and DC-01065 (SAS), The Philip Morris, USA and Philip Morris grant, and the American Physiological Society Lazaro Mandel Young Investigator Award 2000 (III).",

year = "2006",

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doi = "10.1134/S0006350906060078",

language = "English (US)",

volume = "51",

pages = "892--895",

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TY - JOUR

T1 - Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension

AU - Markin, V. S.

AU - Shlyonsky, V. Gh

AU - Simon, S. A.

AU - Benos, D. J.

AU - Ismailov, I. I.

N1 - Funding Information: ACKNOWLEDGMENTS Supported by the National Institute of Health grants DK37206 (DJB), GM-27278 and DC-01065 (SAS), The Philip Morris, USA and Philip Morris grant, and the American Physiological Society Lazaro Mandel Young Investigator Award 2000 (III).

PY - 2006/12

Y1 - 2006/12

N2 - Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity that was proportional to the square of membrane radius, but could not be accounted for by the increase in membrane surface area, or by recruitment of new channels. Extrapolated to biological membranes, these observations may suggest that the permeability of ion channels can be influenced simply by changing shape of the membrane, with or without stretching.

AB - Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity that was proportional to the square of membrane radius, but could not be accounted for by the increase in membrane surface area, or by recruitment of new channels. Extrapolated to biological membranes, these observations may suggest that the permeability of ion channels can be influenced simply by changing shape of the membrane, with or without stretching.

KW - Bilayer lipid membranes

KW - Gramicidin A

KW - Ion channels

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JO - Biophysics

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Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension

Abstract

Keywords

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