Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension

V. S. Markin, V. Gh Shlyonsky, S. A. Simon, D. J. Benos, I. I. Ismailov

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity that was proportional to the square of membrane radius, but could not be accounted for by the increase in membrane surface area, or by recruitment of new channels. Extrapolated to biological membranes, these observations may suggest that the permeability of ion channels can be influenced simply by changing shape of the membrane, with or without stretching.

Original languageEnglish (US)
Pages (from-to)892-895
Number of pages4
JournalBiophysics
Volume51
Issue number6
DOIs
Publication statusPublished - Dec 2006

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Keywords

  • Bilayer lipid membranes
  • Gramicidin A
  • Ion channels

ASJC Scopus subject areas

  • Biophysics

Cite this

Markin, V. S., Shlyonsky, V. G., Simon, S. A., Benos, D. J., & Ismailov, I. I. (2006). Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension. Biophysics, 51(6), 892-895. https://doi.org/10.1134/S0006350906060078