MeCP2 as an Activator of Gene Expression

Patricia M. Horvath; Lisa M Monteggia

doi:10.1016/j.tins.2017.11.005

MeCP2 as an Activator of Gene Expression

Patricia M. Horvath, Lisa M Monteggia

Research output: Contribution to journal › Short survey › peer-review

36 Scopus citations

Abstract

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

Original language	English (US)
Pages (from-to)	72-74
Number of pages	3
Journal	Trends in Neurosciences
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.tins.2017.11.005
State	Published - Feb 2018

ASJC Scopus subject areas

General Neuroscience

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abstract = "Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.",

author = "Horvath, {Patricia M.} and Monteggia, {Lisa M}",

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AU - Monteggia, Lisa M

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AB - Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

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MeCP2 as an Activator of Gene Expression

Abstract

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