MeCP2 as an Activator of Gene Expression

Patricia M. Horvath, Lisa M Monteggia

Research output: Contribution to journalShort survey

11 Scopus citations

Abstract

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

Original languageEnglish (US)
Pages (from-to)72-74
Number of pages3
JournalTrends in Neurosciences
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Neuroscience(all)

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