MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

Kedryn K. Baskin, Chad E. Grueter, Christine M. Kusminski, William L. Holland, Angie L. Bookout, Santosh Satapati, Y. Megan Kong, Shawn C. Burgess, Craig R. Malloy, Philipp E. Scherer, Christopher B. Newgard, Rhonda Bassel-Duby, Eric N. Olson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to cardiac MED13 signaling. We show that cardiac overexpression of MED13 in transgenic (MED13cTg) mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue (WAT) and liver. Cardiac expression of MED13 decreases metabolic gene expression in the heart but enhances them in WAT. Although exhibiting increased energy expenditure in the fed state, MED13cTg mice metabolically adapt to fasting. Furthermore, MED13cTg hearts oxidize fuel that is readily available, rendering them more efficient in the fed state. Parabiosis experiments in which circulations of wild-type and MED13cTg mice are joined, reveal that circulating factor(s) in MED13cTg mice promote enhanced metabolism and leanness. These findings demonstrate that MED13 acts within the heart to promote systemic energy expenditure in extra-cardiac energy depots and point to an unexplored metabolic communication system between the heart and other tissues.

Original languageEnglish (US)
Pages (from-to)1610-1621
Number of pages12
JournalEMBO Molecular Medicine
Volume6
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Thinness
Adipose Tissue
Liver
White Adipose Tissue
Energy Metabolism
Parabiosis
Transgenic Mice
Fasting
Homeostasis
Communication
Phenotype
Lipids
Gene Expression

Keywords

  • Energy homeostasis
  • Mediator complex
  • Metabolic flexibility
  • Metabolic gene expression
  • Metabolism

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. / Baskin, Kedryn K.; Grueter, Chad E.; Kusminski, Christine M.; Holland, William L.; Bookout, Angie L.; Satapati, Santosh; Kong, Y. Megan; Burgess, Shawn C.; Malloy, Craig R.; Scherer, Philipp E.; Newgard, Christopher B.; Bassel-Duby, Rhonda; Olson, Eric N.

In: EMBO Molecular Medicine, Vol. 6, No. 12, 01.12.2014, p. 1610-1621.

Research output: Contribution to journalArticle

Baskin, Kedryn K. ; Grueter, Chad E. ; Kusminski, Christine M. ; Holland, William L. ; Bookout, Angie L. ; Satapati, Santosh ; Kong, Y. Megan ; Burgess, Shawn C. ; Malloy, Craig R. ; Scherer, Philipp E. ; Newgard, Christopher B. ; Bassel-Duby, Rhonda ; Olson, Eric N. / MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. In: EMBO Molecular Medicine. 2014 ; Vol. 6, No. 12. pp. 1610-1621.
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