Medical management of recurrent idiopathic nephrolithiasis

Charles Y C Pak, Clarita V. Odvina

Research output: Contribution to journalArticle

Abstract

This update reviews salient progress in pathophysiology, diagnosis, and medical management. In absorptive hypercalciuria, bone loss accompanies stone formation in some patients. Potential putative gene (soluble adenylyl cyclase) has been identified. The invariant feature in hypocitraturia is low intracellular pH that alters renal tubular metabolism and reabsorption of citrate. In gouty diathesis, uric acid stones develop from low urinary pH, probably resulting from impaired renal ammonia genesis of acquired insulin resistance. The protection against stone formation, conferred by citrus fruits, depends on the potassium content that determines the amount of alkali load delivered. Animal protein excess such as with the Atkins diet confers an acid load that increases urinary calcium and lowers citrate. Dietary calcium restriction lowers urinary calcium and saturation of calcium oxalate among patients with hypercalciuria, but not in those with normocalciuria. A simplified diagnostic evaluation and management may be used among patients with uncomplicated stone disease in an office setting. A 24-hour urine on a random diet should be collected for a full stone risk analysis. Among patients with hypercalciuria, dietary restriction of calcium and oxalate with indapamide (or thiazide) and potassium citrate is recommended. Among normocalciuric patients, liberal calcium intake and potassium citrate should be beneficial.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalEndocrinologist
Volume16
Issue number3
DOIs
StatePublished - May 2006

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Nephrolithiasis
Hypercalciuria
Potassium Citrate
Calcium Citrate
Dietary Calcium
Calcium Oxalate
Indapamide
Carbohydrate-Restricted Diet
Thiazides
Citrus
Disease Susceptibility
Alkalies
Uric Acid
Ammonia
Adenylyl Cyclases
Citric Acid
Insulin Resistance
Potassium
Urine
Diet

Keywords

  • Citrate
  • Hypercalciuria
  • Urinary pH

ASJC Scopus subject areas

  • Endocrinology

Cite this

Medical management of recurrent idiopathic nephrolithiasis. / Pak, Charles Y C; Odvina, Clarita V.

In: Endocrinologist, Vol. 16, No. 3, 05.2006, p. 150-154.

Research output: Contribution to journalArticle

Pak, Charles Y C ; Odvina, Clarita V. / Medical management of recurrent idiopathic nephrolithiasis. In: Endocrinologist. 2006 ; Vol. 16, No. 3. pp. 150-154.
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