Medical prevention of renal stone disease

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Medical treatment designed to prevent stone formation is important in idiopathic calcium oxalate nephrolithiasis, because of the high rate of stone recurrence. Several randomized trials have established the values of conservative and drug treatments. A high fluid intake alone has been reported to inhibit the recurrence of stone formation in single stone formers. In patients with recurrent disease, a significant reduction in stone formation rate from pretreatment was found in the placebo group maintained on a conservative program, underscoring the importance of increased fluid intake and dietary modification. In patients with active recurrent stone disease, treatment with drugs along with a conservative program is necessary. Allopurinol, thiazide, potassium citrate and potassium-magnesium citrate have been shown to inhibit stone formation compared with placebo. It has not been clearly established that a selective treatment is more effective than a more randomly chosen drug treatment. Another advantage of medical approach is its ability to correct nonrenal complications of stone disease, such as bone loss that sometimes accompanies stone disease.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalNephron
Volume81
Issue numberSUPPL. 1
StatePublished - 1999

Fingerprint

Kidney
Potassium Citrate
Placebos
Pharmaceutical Preparations
Thiazides
Diet Therapy
Recurrence
Allopurinol
Therapeutics
Bone and Bones
Calcium Oxalate Nephrolithiasis
potassium-magnesium citrate
Conservative Treatment

Keywords

  • Hypercalciuria
  • Kidney stones
  • Treatment, renal stone disease

ASJC Scopus subject areas

  • Nephrology

Cite this

Medical prevention of renal stone disease. / Pak, Charles Y C.

In: Nephron, Vol. 81, No. SUPPL. 1, 1999, p. 60-65.

Research output: Contribution to journalArticle

Pak, CYC 1999, 'Medical prevention of renal stone disease', Nephron, vol. 81, no. SUPPL. 1, pp. 60-65.
Pak, Charles Y C. / Medical prevention of renal stone disease. In: Nephron. 1999 ; Vol. 81, No. SUPPL. 1. pp. 60-65.
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