Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern; Sandra A. Carson; Huiman X. Barnhart; Evan R. Myers; Richard S. Legro; Michael P. Diamond; Bruce R. Carr; William D. Schlaff; Christos Coutifaris; Nicholas A. Cataldo; Michael P. Steinkampf; John E. Nestler; Gabey Gosman; Phyllis C. Leppert; Linda C. Giudice

doi:10.1016/j.fertnstert.2007.09.004

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern, Sandra A. Carson, Huiman X. Barnhart, Evan R. Myers, Richard S. Legro, Michael P. Diamond, Bruce R. Carr, William D. Schlaff, Christos Coutifaris, Nicholas A. Cataldo, Michael P. Steinkampf, John E. Nestler, Gabey Gosman, Phyllis C. Leppert, Linda C. Giudice

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

Original language	English (US)
Pages (from-to)	1283-1286
Number of pages	4
Journal	Fertility and sterility
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2007.09.004
State	Published - Oct 2008

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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McGovern, P. G., Carson, S. A., Barnhart, H. X., Myers, E. R., Legro, R. S., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., Cataldo, N. A., Steinkampf, M. P., Nestler, J. E., Gosman, G., Leppert, P. C., & Giudice, L. C. (2008). Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. Fertility and sterility, 90(4), 1283-1286. https://doi.org/10.1016/j.fertnstert.2007.09.004

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. / McGovern, Peter G.; Carson, Sandra A.; Barnhart, Huiman X.; Myers, Evan R.; Legro, Richard S.; Diamond, Michael P.; Carr, Bruce R.; Schlaff, William D.; Coutifaris, Christos; Cataldo, Nicholas A.; Steinkampf, Michael P.; Nestler, John E.; Gosman, Gabey; Leppert, Phyllis C.; Giudice, Linda C.

In: Fertility and sterility, Vol. 90, No. 4, 10.2008, p. 1283-1286.

Research output: Contribution to journal › Article › peer-review

McGovern, PG, Carson, SA, Barnhart, HX, Myers, ER, Legro, RS, Diamond, MP, Carr, BR, Schlaff, WD, Coutifaris, C, Cataldo, NA, Steinkampf, MP, Nestler, JE, Gosman, G, Leppert, PC & Giudice, LC 2008, 'Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial', Fertility and sterility, vol. 90, no. 4, pp. 1283-1286. https://doi.org/10.1016/j.fertnstert.2007.09.004

McGovern, Peter G. ; Carson, Sandra A. ; Barnhart, Huiman X. ; Myers, Evan R. ; Legro, Richard S. ; Diamond, Michael P. ; Carr, Bruce R. ; Schlaff, William D. ; Coutifaris, Christos ; Cataldo, Nicholas A. ; Steinkampf, Michael P. ; Nestler, John E. ; Gosman, Gabey ; Leppert, Phyllis C. ; Giudice, Linda C. / Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. In: Fertility and sterility. 2008 ; Vol. 90, No. 4. pp. 1283-1286.

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abstract = "We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.",

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