Medication-induced intracranial hypertension in dermatology

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Pseudotumor cerebri (PTC) is a syndrome of intracranial hypertension that is idiopathic or from an identified secondary cause. It is characterized by headaches and visual manifestations. The hallmark of PTC is papilledema and the feared consequence is visual loss that may be severe and permanent. The idiopathic form generally occurs in obese women of childbearing age. Various medications may produce PTC in patients at any age, including children. Several medications used in dermatology, particularly those used in the treatment of acne vulgaris, are associated with PTC. There is a strong association with tetracycline usage. Minocycline and doxycycline have also been linked to PTC, although there are relatively few reported cases. PTC has also been described with retinoids, including vitamin A (retinol) and isotretinoin. Although corticosteroids are often used to lower intracranial pressure acutely, corticosteroid withdrawal after long-term administration may induce increased intracranial pressure. A high index of suspicion, early diagnosis and treatment generally yield a good prognosis.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalAmerican Journal of Clinical Dermatology
Issue number1
StatePublished - 2005

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Medication-induced intracranial hypertension in dermatology'. Together they form a unique fingerprint.

Cite this