Medication treatment for the severely and persistently mentally ill: The Texas Medication Algorithm Project

A. John Rush, William V. Rago, M. Lynn Crismon, Marcia G. Toprac, Steven P. Shon, Trisha Suppes, Alexander L. Miller, Madhukar H. Trivedi, Alan C. Swann, Melanie M. Biggs, Kathy Shores-Wilson, T. Michael Kashner, Teresa Pigott, John A. Chiles, Don A. Gilbert, Kenneth Z. Altshuler

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

This article provides an overview of the issues involved in developing, using, and evaluating specific medication guidelines for patients with psychiatric disorders. The potential advantages and disadvantages, as well as the essential elements in the structure of algorithms, are illustrated by experience to date with the Texas Medication Algorithm Project, a public- academic collaboration. Phase 1 entailed assembling research findings on the efficacy of medications for schizophrenic, bipolar, and major depressive disorders. This knowledge was evaluated for its quality and relevance, integrated with expert clinical judgment as well as input by practicing clinicians, family advocates, and patients. Phase 1 (the design and development of the algorithms) was followed by a feasibility test (Phase 2). Phase 3 is an ongoing evaluation comparing the clinical and economic effects of using specific medication guidelines (algorithms) versus treatment as usual in public sector patients with severe and persistent mental illnesses.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalJournal of Clinical Psychiatry
Volume60
Issue number5
StatePublished - May 1999

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Mentally Ill Persons
Guidelines
Public Sector
Major Depressive Disorder
Therapeutics
Psychiatry
Economics
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Rush, A. J., Rago, W. V., Crismon, M. L., Toprac, M. G., Shon, S. P., Suppes, T., ... Altshuler, K. Z. (1999). Medication treatment for the severely and persistently mentally ill: The Texas Medication Algorithm Project. Journal of Clinical Psychiatry, 60(5), 284-291.

Medication treatment for the severely and persistently mentally ill : The Texas Medication Algorithm Project. / Rush, A. John; Rago, William V.; Crismon, M. Lynn; Toprac, Marcia G.; Shon, Steven P.; Suppes, Trisha; Miller, Alexander L.; Trivedi, Madhukar H.; Swann, Alan C.; Biggs, Melanie M.; Shores-Wilson, Kathy; Kashner, T. Michael; Pigott, Teresa; Chiles, John A.; Gilbert, Don A.; Altshuler, Kenneth Z.

In: Journal of Clinical Psychiatry, Vol. 60, No. 5, 05.1999, p. 284-291.

Research output: Contribution to journalArticle

Rush, AJ, Rago, WV, Crismon, ML, Toprac, MG, Shon, SP, Suppes, T, Miller, AL, Trivedi, MH, Swann, AC, Biggs, MM, Shores-Wilson, K, Kashner, TM, Pigott, T, Chiles, JA, Gilbert, DA & Altshuler, KZ 1999, 'Medication treatment for the severely and persistently mentally ill: The Texas Medication Algorithm Project', Journal of Clinical Psychiatry, vol. 60, no. 5, pp. 284-291.
Rush AJ, Rago WV, Crismon ML, Toprac MG, Shon SP, Suppes T et al. Medication treatment for the severely and persistently mentally ill: The Texas Medication Algorithm Project. Journal of Clinical Psychiatry. 1999 May;60(5):284-291.
Rush, A. John ; Rago, William V. ; Crismon, M. Lynn ; Toprac, Marcia G. ; Shon, Steven P. ; Suppes, Trisha ; Miller, Alexander L. ; Trivedi, Madhukar H. ; Swann, Alan C. ; Biggs, Melanie M. ; Shores-Wilson, Kathy ; Kashner, T. Michael ; Pigott, Teresa ; Chiles, John A. ; Gilbert, Don A. ; Altshuler, Kenneth Z. / Medication treatment for the severely and persistently mentally ill : The Texas Medication Algorithm Project. In: Journal of Clinical Psychiatry. 1999 ; Vol. 60, No. 5. pp. 284-291.
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