Abstract
Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001). Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.
Original language | English (US) |
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Pages (from-to) | 186-192 |
Number of pages | 7 |
Journal | Dementia and Geriatric Cognitive Disorders |
Volume | 46 |
Issue number | 3-4 |
DOIs | |
State | Published - Nov 1 2018 |
Keywords
- Alzheimer's disease
- Independence
- Outcome measure
- Social engagement
- Wellbeing
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Cognitive Neuroscience
- Psychiatry and Mental health