Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers

Research output: Contribution to journalArticle

Abstract

Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001). Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.

Original languageEnglish (US)
Pages (from-to)186-192
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Megestrol
Megestrol Acetate
Hydrocortisone
Healthy Volunteers
Phenytoin
Placebos
Verbal Learning
Aptitude
Glucocorticoid Receptors
Progesterone Receptors
Cross-Over Studies

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

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title = "Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers",
abstract = "Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001). Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.",
author = "Mason, {Brittany L.} and Ivleva, {Elena I.} and {Van Enkevort}, Erin and Alyson Nakamura and Brown, {E. Sherwood}",
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doi = "10.1159/000490789",
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T1 - Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers

AU - Mason, Brittany L.

AU - Ivleva, Elena I.

AU - Van Enkevort, Erin

AU - Nakamura, Alyson

AU - Brown, E. Sherwood

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N2 - Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001). Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.

AB - Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001). Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.

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