Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers

Research output: Contribution to journalArticle


Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001). Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.

Original languageEnglish (US)
Pages (from-to)186-192
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
StateAccepted/In press - Jan 1 2018


ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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