Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary

Yun Li, Qiao Zhang, Arnaldo Carreira-Rosario, Jean Z. Maines, Dennis M. McKearin, Michael Buszczak

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.

Original languageEnglish (US)
Article numbere58301
JournalPLoS One
Volume8
Issue number3
DOIs
StatePublished - Mar 20 2013

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Protein Biosynthesis
translation (genetics)
Drosophila
Ovary
germ cells
Messenger RNA
stem cells
Cysts
Cell Differentiation
Stem Cells
Maintenance
Stem cells
Proteins
proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary. / Li, Yun; Zhang, Qiao; Carreira-Rosario, Arnaldo; Maines, Jean Z.; McKearin, Dennis M.; Buszczak, Michael.

In: PLoS One, Vol. 8, No. 3, e58301, 20.03.2013.

Research output: Contribution to journalArticle

Li, Yun ; Zhang, Qiao ; Carreira-Rosario, Arnaldo ; Maines, Jean Z. ; McKearin, Dennis M. ; Buszczak, Michael. / Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary. In: PLoS One. 2013 ; Vol. 8, No. 3.
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