Meibomian gland function and the tear lipid layer

James P McCulley, Ward E. Shine

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalOcular Surface
Volume1
Issue number3
StatePublished - Jul 2003

Fingerprint

Meibomian Glands
Tears
Lipids
Bacteria
Lipase
Nonesterified Fatty Acids
Surface-Active Agents

Keywords

  • Chronic blepharitis
  • Dry eye
  • Lipids
  • Meibomian gland

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Meibomian gland function and the tear lipid layer. / McCulley, James P; Shine, Ward E.

In: Ocular Surface, Vol. 1, No. 3, 07.2003, p. 97-106.

Research output: Contribution to journalArticle

McCulley, JP & Shine, WE 2003, 'Meibomian gland function and the tear lipid layer', Ocular Surface, vol. 1, no. 3, pp. 97-106.
McCulley, James P ; Shine, Ward E. / Meibomian gland function and the tear lipid layer. In: Ocular Surface. 2003 ; Vol. 1, No. 3. pp. 97-106.
@article{cdf80ad5745744ab9fcaab7bd1fd8203,
title = "Meibomian gland function and the tear lipid layer",
abstract = "The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.",
keywords = "Chronic blepharitis, Dry eye, Lipids, Meibomian gland",
author = "McCulley, {James P} and Shine, {Ward E.}",
year = "2003",
month = "7",
language = "English (US)",
volume = "1",
pages = "97--106",
journal = "Ocular Surface",
issn = "1542-0124",
publisher = "Ethis Communications, Inc.",
number = "3",

}

TY - JOUR

T1 - Meibomian gland function and the tear lipid layer

AU - McCulley, James P

AU - Shine, Ward E.

PY - 2003/7

Y1 - 2003/7

N2 - The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.

AB - The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.

KW - Chronic blepharitis

KW - Dry eye

KW - Lipids

KW - Meibomian gland

UR - http://www.scopus.com/inward/record.url?scp=11144227505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144227505&partnerID=8YFLogxK

M3 - Article

C2 - 17075642

AN - SCOPUS:11144227505

VL - 1

SP - 97

EP - 106

JO - Ocular Surface

JF - Ocular Surface

SN - 1542-0124

IS - 3

ER -