Meibomian keratoconjunctivitis

James P McCulley, G. F. Sciallis

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

We evaluated, dermatologically and ophthalmologically, 26 patients who had chronic blepharitis (meibomitis); we also investigated 26 age- and sex-matched controls. All of the blepharitic patients had an abnormality of sebaceous gland function ranging from seborrhea sicca to seborrheic dermatitis or acne rosacea, suggesting a generalized sebaceous gland dysfunction that included the meibomian glands. Sebaceous gland abnormalities most frequently involved the cool areas of the face or scalp. Stagnation of the meibomian glands presumably caused a defect in the tear lipid layer; this resulted in an unstable tear film that produced superficial punctate keratopathy. The break-up time was much lower in these patients than in controls. The break-up time returned to normal or super-normal levels when fresh meibomian secretions were expressed into the tear film. The superficial punctate keratopathy had the characteristics of those seen in conditions with a known unstable tear film and not of those experimentally produced by staphylococcus toxin.

Original languageEnglish (US)
Pages (from-to)788-793
Number of pages6
JournalAmerican Journal of Ophthalmology
Volume84
Issue number6
StatePublished - 1977

Fingerprint

Keratoconjunctivitis
Tears
Sebaceous Glands
Meibomian Glands
Seborrheic Dermatitis
Blepharitis
Rosacea
Scalp
Staphylococcus
Lipids

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Meibomian keratoconjunctivitis. / McCulley, James P; Sciallis, G. F.

In: American Journal of Ophthalmology, Vol. 84, No. 6, 1977, p. 788-793.

Research output: Contribution to journalArticle

McCulley, JP & Sciallis, GF 1977, 'Meibomian keratoconjunctivitis', American Journal of Ophthalmology, vol. 84, no. 6, pp. 788-793.
McCulley, James P ; Sciallis, G. F. / Meibomian keratoconjunctivitis. In: American Journal of Ophthalmology. 1977 ; Vol. 84, No. 6. pp. 788-793.
@article{301132cf4e9f4107acd1debc040c71d6,
title = "Meibomian keratoconjunctivitis",
abstract = "We evaluated, dermatologically and ophthalmologically, 26 patients who had chronic blepharitis (meibomitis); we also investigated 26 age- and sex-matched controls. All of the blepharitic patients had an abnormality of sebaceous gland function ranging from seborrhea sicca to seborrheic dermatitis or acne rosacea, suggesting a generalized sebaceous gland dysfunction that included the meibomian glands. Sebaceous gland abnormalities most frequently involved the cool areas of the face or scalp. Stagnation of the meibomian glands presumably caused a defect in the tear lipid layer; this resulted in an unstable tear film that produced superficial punctate keratopathy. The break-up time was much lower in these patients than in controls. The break-up time returned to normal or super-normal levels when fresh meibomian secretions were expressed into the tear film. The superficial punctate keratopathy had the characteristics of those seen in conditions with a known unstable tear film and not of those experimentally produced by staphylococcus toxin.",
author = "McCulley, {James P} and Sciallis, {G. F.}",
year = "1977",
language = "English (US)",
volume = "84",
pages = "788--793",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Meibomian keratoconjunctivitis

AU - McCulley, James P

AU - Sciallis, G. F.

PY - 1977

Y1 - 1977

N2 - We evaluated, dermatologically and ophthalmologically, 26 patients who had chronic blepharitis (meibomitis); we also investigated 26 age- and sex-matched controls. All of the blepharitic patients had an abnormality of sebaceous gland function ranging from seborrhea sicca to seborrheic dermatitis or acne rosacea, suggesting a generalized sebaceous gland dysfunction that included the meibomian glands. Sebaceous gland abnormalities most frequently involved the cool areas of the face or scalp. Stagnation of the meibomian glands presumably caused a defect in the tear lipid layer; this resulted in an unstable tear film that produced superficial punctate keratopathy. The break-up time was much lower in these patients than in controls. The break-up time returned to normal or super-normal levels when fresh meibomian secretions were expressed into the tear film. The superficial punctate keratopathy had the characteristics of those seen in conditions with a known unstable tear film and not of those experimentally produced by staphylococcus toxin.

AB - We evaluated, dermatologically and ophthalmologically, 26 patients who had chronic blepharitis (meibomitis); we also investigated 26 age- and sex-matched controls. All of the blepharitic patients had an abnormality of sebaceous gland function ranging from seborrhea sicca to seborrheic dermatitis or acne rosacea, suggesting a generalized sebaceous gland dysfunction that included the meibomian glands. Sebaceous gland abnormalities most frequently involved the cool areas of the face or scalp. Stagnation of the meibomian glands presumably caused a defect in the tear lipid layer; this resulted in an unstable tear film that produced superficial punctate keratopathy. The break-up time was much lower in these patients than in controls. The break-up time returned to normal or super-normal levels when fresh meibomian secretions were expressed into the tear film. The superficial punctate keratopathy had the characteristics of those seen in conditions with a known unstable tear film and not of those experimentally produced by staphylococcus toxin.

UR - http://www.scopus.com/inward/record.url?scp=0017607806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017607806&partnerID=8YFLogxK

M3 - Article

C2 - 145804

AN - SCOPUS:0017607806

VL - 84

SP - 788

EP - 793

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 6

ER -