Melanocortin neurons

Multiple routes to regulation of metabolism

Wen jie Shen, Ting Yao, Xingxing Kong, Kevin W. Williams, Tiemin Liu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the energetic state Although the primary cause of obesity is unknown, there is significant effort to understand the role of the central melanocortin pathway in the brain as it has been shown that deficiency of proopiomelanocortin (POMC) and melanocortin 4 receptors (MC4R) in both rodents and humans results in severe hyperphagia and obesity In this review, we will summarize how the central melanocortin pathway helps regulate body mass and adiposity within a 'healthy' range through the 'nutrient sensing' network This article is part of a Special Issue entitled: Melanocortin Receptors - edited by Ya-Xiong Tao.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
DOIs
StateAccepted/In press - Jan 17 2017

Fingerprint

Melanocortins
Obesity
Neurons
Melanocortin Receptors
Receptor, Melanocortin, Type 4
Hyperphagia
Body Weight Changes
Premature Mortality
Morbid Obesity
Adiposity
Metabolic Networks and Pathways
Health Care Costs
Type 2 Diabetes Mellitus
Mammals
Rodentia
Cardiovascular Diseases
Stroke
Economics
Hypertension
Food

Keywords

  • Agouti related peptide neurons
  • Central melanocortin pathway
  • Melanocortin 4 receptors
  • Metabolism
  • Proopiomelanocortin neurons

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Melanocortin neurons : Multiple routes to regulation of metabolism. / Shen, Wen jie; Yao, Ting; Kong, Xingxing; Williams, Kevin W.; Liu, Tiemin.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 17.01.2017.

Research output: Contribution to journalArticle

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