Membrane ecto-ATPase on epidermal Langerhans cells

Giampiero Girolomoni, Maria Lucia Santantonio, Paul R. Bergstresser, Ponciano D Cruz, Alberto Giannetti

Research output: Contribution to journalArticle

Abstract

Epidermal Langerhans cells (LC) possess a plasma membrane Mg++- or Ca++-dependent ecto-ATPase (mATPase), the function of which is not known. On the other hand, extracellular ATP (ATP°) has been shown to cause a rapid increase in cell-membrane permeability for selected cells, thus inducing the entry of exogenous substances, leading eventually to cell death. ATP°has also been shown to be a mediator of T cell - mediated cytotoxicity. We have observed human LC to be resistant to the permeabilizing effects of ATP°when compared to cultured human keratinocytes and J774 macrophages. In addition, our preliminary evidence in vitro suggests that mATPase on LC may provide protection against the lytic effects of ATP°. Finally, we propose that this latter mechanism may also operate in vivo.

Original languageEnglish (US)
Pages (from-to)12-14
Number of pages3
JournalJournal of Investigative Dermatology
Volume99
Issue number5
StatePublished - Nov 1992

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Langerhans Cells
Adenosine Triphosphate
Cell membranes
Membranes
Cell Membrane Permeability
T-cells
Macrophages
Cell death
Cytotoxicity
Keratinocytes
Cell Death
Cell Membrane
T-Lymphocytes
ectoATPase

ASJC Scopus subject areas

  • Dermatology

Cite this

Girolomoni, G., Santantonio, M. L., Bergstresser, P. R., Cruz, P. D., & Giannetti, A. (1992). Membrane ecto-ATPase on epidermal Langerhans cells. Journal of Investigative Dermatology, 99(5), 12-14.

Membrane ecto-ATPase on epidermal Langerhans cells. / Girolomoni, Giampiero; Santantonio, Maria Lucia; Bergstresser, Paul R.; Cruz, Ponciano D; Giannetti, Alberto.

In: Journal of Investigative Dermatology, Vol. 99, No. 5, 11.1992, p. 12-14.

Research output: Contribution to journalArticle

Girolomoni, G, Santantonio, ML, Bergstresser, PR, Cruz, PD & Giannetti, A 1992, 'Membrane ecto-ATPase on epidermal Langerhans cells', Journal of Investigative Dermatology, vol. 99, no. 5, pp. 12-14.
Girolomoni G, Santantonio ML, Bergstresser PR, Cruz PD, Giannetti A. Membrane ecto-ATPase on epidermal Langerhans cells. Journal of Investigative Dermatology. 1992 Nov;99(5):12-14.
Girolomoni, Giampiero ; Santantonio, Maria Lucia ; Bergstresser, Paul R. ; Cruz, Ponciano D ; Giannetti, Alberto. / Membrane ecto-ATPase on epidermal Langerhans cells. In: Journal of Investigative Dermatology. 1992 ; Vol. 99, No. 5. pp. 12-14.
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