Membrane-encased polymer millirods for sustained release of 5-fluorouracil

Feng Qian, Norased Nasongkla, Jinming Gao

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This article describes the design and development of a novel membrane-encased polymer millirod for the sustained release of an anticancer drug, 5-fluorouracil (5-FU). The millirod consists of two functional compartments: (1) an inner 5-FU-loaded monolithic millirod as the drug depot, and (2) an outer NaCl-impregnated polymer membrane to control the release rate of 5-FU. The inner millirod is fabricated by a compression-heat molding procedure to permit the entrapment of 5-FU particles in the poly(D,L-lactide-co-glycolide) (PLGA) matrix. The drug loading density is controlled at 30 w/w% to achieve a burst release of 5-FU (>90% of the drug are released within 48 h) from the monolithic millirod. The NaCl-impregnated PLGA membrane is generated by solvent casting and is then wrapped over the monolithic millirod to produce the membrane-encased millirod. Scanning electron microscopy shows that dissolution of NaCl particles produces a semipermeable polymer membrane to provide a sustained release of 5-FU. The membrane thickness and the density of NaCl particles inside the membrane are useful parameters to control the release kinetics of 5-FU. Under the experimental conditions in this study, sustained release of 5-FU [rates between 0.1 and 0.4 mg/(day cm of millirod)] is achieved for 2 to 5 weeks in phosphate-buffered saline (pH 7.4) at 37°C. Results from this study demonstrate that membrane-encased polymer millirods provide controllable sustained release kinetics for applications in intratumoral drug delivery.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalJournal of Biomedical Materials Research
Volume61
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Fluorouracil
Polymers
Membranes
Pharmaceutical Preparations
Kinetics
Drug delivery
Molding
Casting
Dissolution
Phosphates
Compaction
Scanning electron microscopy
polylactic acid-polyglycolic acid copolymer

Keywords

  • 5-fluorouracil
  • Controlled release drug delivery
  • Intratumoral drug delivery
  • Poly(D,L-lactide-co-glycolide)

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Membrane-encased polymer millirods for sustained release of 5-fluorouracil. / Qian, Feng; Nasongkla, Norased; Gao, Jinming.

In: Journal of Biomedical Materials Research, Vol. 61, No. 2, 2002, p. 203-211.

Research output: Contribution to journalArticle

@article{7850d8df37c4468bbfb1045a0bffe29b,
title = "Membrane-encased polymer millirods for sustained release of 5-fluorouracil",
abstract = "This article describes the design and development of a novel membrane-encased polymer millirod for the sustained release of an anticancer drug, 5-fluorouracil (5-FU). The millirod consists of two functional compartments: (1) an inner 5-FU-loaded monolithic millirod as the drug depot, and (2) an outer NaCl-impregnated polymer membrane to control the release rate of 5-FU. The inner millirod is fabricated by a compression-heat molding procedure to permit the entrapment of 5-FU particles in the poly(D,L-lactide-co-glycolide) (PLGA) matrix. The drug loading density is controlled at 30 w/w{\%} to achieve a burst release of 5-FU (>90{\%} of the drug are released within 48 h) from the monolithic millirod. The NaCl-impregnated PLGA membrane is generated by solvent casting and is then wrapped over the monolithic millirod to produce the membrane-encased millirod. Scanning electron microscopy shows that dissolution of NaCl particles produces a semipermeable polymer membrane to provide a sustained release of 5-FU. The membrane thickness and the density of NaCl particles inside the membrane are useful parameters to control the release kinetics of 5-FU. Under the experimental conditions in this study, sustained release of 5-FU [rates between 0.1 and 0.4 mg/(day cm of millirod)] is achieved for 2 to 5 weeks in phosphate-buffered saline (pH 7.4) at 37°C. Results from this study demonstrate that membrane-encased polymer millirods provide controllable sustained release kinetics for applications in intratumoral drug delivery.",
keywords = "5-fluorouracil, Controlled release drug delivery, Intratumoral drug delivery, Poly(D,L-lactide-co-glycolide)",
author = "Feng Qian and Norased Nasongkla and Jinming Gao",
year = "2002",
doi = "10.1002/jbm.10156",
language = "English (US)",
volume = "61",
pages = "203--211",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "0021-9304",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Membrane-encased polymer millirods for sustained release of 5-fluorouracil

AU - Qian, Feng

AU - Nasongkla, Norased

AU - Gao, Jinming

PY - 2002

Y1 - 2002

N2 - This article describes the design and development of a novel membrane-encased polymer millirod for the sustained release of an anticancer drug, 5-fluorouracil (5-FU). The millirod consists of two functional compartments: (1) an inner 5-FU-loaded monolithic millirod as the drug depot, and (2) an outer NaCl-impregnated polymer membrane to control the release rate of 5-FU. The inner millirod is fabricated by a compression-heat molding procedure to permit the entrapment of 5-FU particles in the poly(D,L-lactide-co-glycolide) (PLGA) matrix. The drug loading density is controlled at 30 w/w% to achieve a burst release of 5-FU (>90% of the drug are released within 48 h) from the monolithic millirod. The NaCl-impregnated PLGA membrane is generated by solvent casting and is then wrapped over the monolithic millirod to produce the membrane-encased millirod. Scanning electron microscopy shows that dissolution of NaCl particles produces a semipermeable polymer membrane to provide a sustained release of 5-FU. The membrane thickness and the density of NaCl particles inside the membrane are useful parameters to control the release kinetics of 5-FU. Under the experimental conditions in this study, sustained release of 5-FU [rates between 0.1 and 0.4 mg/(day cm of millirod)] is achieved for 2 to 5 weeks in phosphate-buffered saline (pH 7.4) at 37°C. Results from this study demonstrate that membrane-encased polymer millirods provide controllable sustained release kinetics for applications in intratumoral drug delivery.

AB - This article describes the design and development of a novel membrane-encased polymer millirod for the sustained release of an anticancer drug, 5-fluorouracil (5-FU). The millirod consists of two functional compartments: (1) an inner 5-FU-loaded monolithic millirod as the drug depot, and (2) an outer NaCl-impregnated polymer membrane to control the release rate of 5-FU. The inner millirod is fabricated by a compression-heat molding procedure to permit the entrapment of 5-FU particles in the poly(D,L-lactide-co-glycolide) (PLGA) matrix. The drug loading density is controlled at 30 w/w% to achieve a burst release of 5-FU (>90% of the drug are released within 48 h) from the monolithic millirod. The NaCl-impregnated PLGA membrane is generated by solvent casting and is then wrapped over the monolithic millirod to produce the membrane-encased millirod. Scanning electron microscopy shows that dissolution of NaCl particles produces a semipermeable polymer membrane to provide a sustained release of 5-FU. The membrane thickness and the density of NaCl particles inside the membrane are useful parameters to control the release kinetics of 5-FU. Under the experimental conditions in this study, sustained release of 5-FU [rates between 0.1 and 0.4 mg/(day cm of millirod)] is achieved for 2 to 5 weeks in phosphate-buffered saline (pH 7.4) at 37°C. Results from this study demonstrate that membrane-encased polymer millirods provide controllable sustained release kinetics for applications in intratumoral drug delivery.

KW - 5-fluorouracil

KW - Controlled release drug delivery

KW - Intratumoral drug delivery

KW - Poly(D,L-lactide-co-glycolide)

UR - http://www.scopus.com/inward/record.url?scp=0036273221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036273221&partnerID=8YFLogxK

U2 - 10.1002/jbm.10156

DO - 10.1002/jbm.10156

M3 - Article

C2 - 12007200

AN - SCOPUS:0036273221

VL - 61

SP - 203

EP - 211

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 0021-9304

IS - 2

ER -