Membrane protein structure predictions for exploration

Nick V. Grishin

doi:10.1016/j.cell.2012.06.004

Membrane protein structure predictions for exploration

Research output: Contribution to journal › Short survey › peer-review

Abstract

A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.

Original language	English (US)
Pages (from-to)	1424-1425
Number of pages	2
Journal	Cell
Volume	149
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2012.06.004
State	Published - Jun 22 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2012.06.004

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title = "Membrane protein structure predictions for exploration",

abstract = "A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.",

author = "Grishin, {Nick V.}",

note = "Funding Information: This work was supported, in part, by the National Institutes of Health (GM094575 to N.V.G.) and the Welch Foundation (I-1505 to N.V.G.).",

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AU - Grishin, Nick V.

N1 - Funding Information: This work was supported, in part, by the National Institutes of Health (GM094575 to N.V.G.) and the Welch Foundation (I-1505 to N.V.G.).

PY - 2012/6/22

Y1 - 2012/6/22

N2 - A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.

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DO - 10.1016/j.cell.2012.06.004

M3 - Short survey

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SP - 1424

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JO - Cell

JF - Cell

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Membrane protein structure predictions for exploration

Abstract

ASJC Scopus subject areas

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