Membrane trafficking in neuronal maintenance and degeneration

Dong Wang, Chih Chiang Chan, Smita Cherry, P. Robin Hiesinger

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Defects in membrane trafficking and degradation are hallmarks of most, and maybe all, neurodegenerative disorders. Such defects typically result in the accumulation of undegraded proteins due to aberrant endosomal sorting, lysosomal degradation, or autophagy. The genetic or environmental cause of a specific disease may directly affect these membrane trafficking processes. Alternatively, changes in intracellular sorting and degradation can occur as cellular responses of degenerating neurons to unrelated primary defects such as insoluble protein aggregates or other neurotoxic insults. Importantly, altered membrane trafficking may contribute to the pathogenesis or indeed protect the neuron. The observation of dramatic changes to membrane trafficking thus comes with the challenging need to distinguish pathological from protective alterations. Here, we will review our current knowledge about the protective and destructive roles of membrane trafficking in neuronal maintenance and degeneration. In particular, we will first focus on the question of what type of membrane trafficking keeps healthy neurons alive in the first place. Next, we will discuss what alterations of membrane trafficking are known to occur in Alzheimer's disease and other tauopathies, Parkinson's disease, polyQ diseases, peripheral neuropathies, and lysosomal storage disorders. Combining the maintenance and degeneration viewpoints may yield insight into how to distinguish when membrane trafficking functions protectively or contributes to degeneration.

Original languageEnglish (US)
Pages (from-to)2919-2934
Number of pages16
JournalCellular and Molecular Life Sciences
Volume70
Issue number16
DOIs
StatePublished - Aug 2013

Fingerprint

Maintenance
Membranes
Neurons
Tauopathies
Autophagy
Peripheral Nervous System Diseases
Neurodegenerative Diseases
Parkinson Disease
Alzheimer Disease
Observation
Proteins

Keywords

  • Alzheimer
  • Autophagy
  • Endosome
  • Huntington
  • Lysosome
  • Parkinson

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Membrane trafficking in neuronal maintenance and degeneration. / Wang, Dong; Chan, Chih Chiang; Cherry, Smita; Hiesinger, P. Robin.

In: Cellular and Molecular Life Sciences, Vol. 70, No. 16, 08.2013, p. 2919-2934.

Research output: Contribution to journalArticle

Wang, Dong ; Chan, Chih Chiang ; Cherry, Smita ; Hiesinger, P. Robin. / Membrane trafficking in neuronal maintenance and degeneration. In: Cellular and Molecular Life Sciences. 2013 ; Vol. 70, No. 16. pp. 2919-2934.
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