Membranous nephropathy: A ten-year journey of discoveries

Qi Cai; Allen R. Hendricks

doi:10.1053/j.semdp.2020.01.001

Membranous nephropathy: A ten-year journey of discoveries

Qi Cai, Allen R. Hendricks

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Over the last decade important research discoveries have revealed that most “idiopathic” cases are caused by autoantibodies to podocyte antigens including phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A). In this review, we will discuss the histopathology of primary MN, recent revelations regarding pathogenesis, and ancillary tests.

Original language	English (US)
Pages (from-to)	116-120
Number of pages	5
Journal	Seminars in Diagnostic Pathology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1053/j.semdp.2020.01.001
State	Published - May 2020

Keywords

Membranous nephropathy
PLA2R
THSD7A

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1053/j.semdp.2020.01.001

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title = "Membranous nephropathy: A ten-year journey of discoveries",

abstract = "Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Over the last decade important research discoveries have revealed that most “idiopathic” cases are caused by autoantibodies to podocyte antigens including phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A). In this review, we will discuss the histopathology of primary MN, recent revelations regarding pathogenesis, and ancillary tests.",

keywords = "Membranous nephropathy, PLA2R, THSD7A",

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AB - Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Over the last decade important research discoveries have revealed that most “idiopathic” cases are caused by autoantibodies to podocyte antigens including phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A). In this review, we will discuss the histopathology of primary MN, recent revelations regarding pathogenesis, and ancillary tests.

KW - Membranous nephropathy

KW - PLA2R

KW - THSD7A

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Membranous nephropathy: A ten-year journey of discoveries

Abstract

Keywords

ASJC Scopus subject areas

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