Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen

Rance E. Berg, Emily Crossley, Sean Murray, James Forman

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Interferon (IFN)-γ plays an important role in the innate immune response against intracellular bacterial pathogens. It is commonly thought that natural killer cells are the primary source of this cytokine that is involved in activating antibacterial effects in infected cells and polarizing CD4 + T cells toward the Th1 subset. However, here we show that both effector and memory CD8+ T cells have the potential to secrete IFN-γ response to interleukin (IL)-12 and IL-18 in the absence of cognate antigen. We demonstrate that memory CD8+ T cells specific for the ovalbumin protein secrete IFN-γ rapidly after infection with wild-type Listeria monocytogenes (LM). Furthermore, small numbers of ovalbumin-specific, memory CD8+ T cells can reduce spleen and liver bacterial counts in IFN-γ-deficient mice 3 d after LM infection. Up-regulation of the receptors for IL-12 and IL-18 provides a mechanism for the ability of memory CD8+ T cells to respond in this antigen nonspecific manner. Thus, CD8+ T cells play an important role in the innate immune response against intracellular pathogens by rapidly secreting IFN-γ in response to IL-12 and IL-18.

Original languageEnglish (US)
Pages (from-to)1583-1593
Number of pages11
JournalJournal of Experimental Medicine
Volume198
Issue number10
DOIs
StatePublished - Nov 17 2003

Fingerprint

Listeria monocytogenes
Interferons
T-Lymphocytes
Antigens
Interleukin-18
Ovalbumin
Interleukin-12
Innate Immunity
Interleukin-12 Receptors
Listeriosis
Bacterial Load
Natural Killer Cells
Up-Regulation
Spleen
Cytokines
Liver
Infection
Proteins

Keywords

  • Cytokines
  • IFN-γ
  • Innate immunity
  • Listeria monocytogenes
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen. / Berg, Rance E.; Crossley, Emily; Murray, Sean; Forman, James.

In: Journal of Experimental Medicine, Vol. 198, No. 10, 17.11.2003, p. 1583-1593.

Research output: Contribution to journalArticle

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