TY - JOUR
T1 - Mendelian disorders and multifactorial traits
T2 - The big divide or one for all?
AU - Antonarakis, Stylianos E.
AU - Chakravarti, Aravinda
AU - Cohen, Jonathan C.
AU - Hardy, John
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/5
Y1 - 2010/5
N2 - For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide ĝ€" or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
AB - For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide ĝ€" or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
UR - http://www.scopus.com/inward/record.url?scp=77951131269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951131269&partnerID=8YFLogxK
U2 - 10.1038/nrg2793
DO - 10.1038/nrg2793
M3 - Review article
C2 - 20395971
AN - SCOPUS:77951131269
SN - 1471-0056
VL - 11
SP - 380
EP - 384
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 5
ER -