Mendelian disorders and multifactorial traits: The big divide or one for all?

Stylianos E. Antonarakis, Aravinda Chakravarti, Jonathan C. Cohen, John Hardy

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide ĝ€" or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalNature Reviews Genetics
Volume11
Issue number5
DOIs
StatePublished - May 1 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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