Mental disorders among alcoholics: Relationship to age of onset and cerebrospinal fluid neuropeptides

Alee Roy, Judith Dejong, Danuta Lamparski, Bryon Adinoff, Ted George, Veronica Moore, Debra Garnett, Michael Kerich, Markku Linnoila

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial personality traits, drug abuse, tripolar disorder, panic disorder, suicide attempts, and paternal alcoholism than alcoholics with onset after age 20 years. Alcoholics with onset before and after 20 years of age also differed significantly from each other for cerebrospinal fluid concentrations of diazepam-binding inhibitor and somatostatin. These results support the notion that age of onset may delineate subgroups of alcoholics with significant clinical and neurochemical differences.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalArchives of General Psychiatry
Volume48
Issue number5
StatePublished - 1991

Fingerprint

Alcoholics
Neuropeptides
Age of Onset
Mental Disorders
Cerebrospinal Fluid
Diazepam Binding Inhibitor
Antisocial Personality Disorder
Panic Disorder
Somatostatin
Suicide
Alcoholism
Drinking
Substance-Related Disorders
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Roy, A., Dejong, J., Lamparski, D., Adinoff, B., George, T., Moore, V., ... Linnoila, M. (1991). Mental disorders among alcoholics: Relationship to age of onset and cerebrospinal fluid neuropeptides. Archives of General Psychiatry, 48(5), 423-427.

Mental disorders among alcoholics : Relationship to age of onset and cerebrospinal fluid neuropeptides. / Roy, Alee; Dejong, Judith; Lamparski, Danuta; Adinoff, Bryon; George, Ted; Moore, Veronica; Garnett, Debra; Kerich, Michael; Linnoila, Markku.

In: Archives of General Psychiatry, Vol. 48, No. 5, 1991, p. 423-427.

Research output: Contribution to journalArticle

Roy, A, Dejong, J, Lamparski, D, Adinoff, B, George, T, Moore, V, Garnett, D, Kerich, M & Linnoila, M 1991, 'Mental disorders among alcoholics: Relationship to age of onset and cerebrospinal fluid neuropeptides', Archives of General Psychiatry, vol. 48, no. 5, pp. 423-427.
Roy A, Dejong J, Lamparski D, Adinoff B, George T, Moore V et al. Mental disorders among alcoholics: Relationship to age of onset and cerebrospinal fluid neuropeptides. Archives of General Psychiatry. 1991;48(5):423-427.
Roy, Alee ; Dejong, Judith ; Lamparski, Danuta ; Adinoff, Bryon ; George, Ted ; Moore, Veronica ; Garnett, Debra ; Kerich, Michael ; Linnoila, Markku. / Mental disorders among alcoholics : Relationship to age of onset and cerebrospinal fluid neuropeptides. In: Archives of General Psychiatry. 1991 ; Vol. 48, No. 5. pp. 423-427.
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