TY - JOUR
T1 - Mental Disorders Among Alcoholics
T2 - Relationship to Age of Onset and Cerebrospinal Fluid Neuropeptides
AU - Roy, Alee
AU - Dejong, Judith
AU - Lamparski, Danuta
AU - Adinoff, Bryon
AU - George, Ted
AU - Moore, Veronica
AU - Garnett, Debra
AU - Kerich, Michael
AU - Linnoila, Markku
PY - 1991/5
Y1 - 1991/5
N2 - • Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial personality traits, drug abuse, bipolar disorder, panic disorder, suicide attempts, and paternal alcoholism than alcoholics with onset after age 20 years. Alcoholics with onset before and after 20 years of age also differed significantly from each other for cerebrospinal fluid concentrations of diazepam-binding inhibitor and somatostatin. These results support the notion that age of onset may delineate subgroups of alcoholics with significant clinical and neurochemical differences.
AB - • Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial personality traits, drug abuse, bipolar disorder, panic disorder, suicide attempts, and paternal alcoholism than alcoholics with onset after age 20 years. Alcoholics with onset before and after 20 years of age also differed significantly from each other for cerebrospinal fluid concentrations of diazepam-binding inhibitor and somatostatin. These results support the notion that age of onset may delineate subgroups of alcoholics with significant clinical and neurochemical differences.
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U2 - 10.1001/archpsyc.1991.01810290035006
DO - 10.1001/archpsyc.1991.01810290035006
M3 - Article
C2 - 1673594
AN - SCOPUS:0025774381
SN - 0003-990X
VL - 48
SP - 423
EP - 427
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 5
ER -