Mental Disorders Among Alcoholics: Relationship to Age of Onset and Cerebrospinal Fluid Neuropeptides

Alee Roy, Judith Dejong, Danuta Lamparski, Bryon Adinoff, Ted George, Veronica Moore, Debra Garnett, Michael Kerich, Markku Linnoila

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

• Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial personality traits, drug abuse, bipolar disorder, panic disorder, suicide attempts, and paternal alcoholism than alcoholics with onset after age 20 years. Alcoholics with onset before and after 20 years of age also differed significantly from each other for cerebrospinal fluid concentrations of diazepam-binding inhibitor and somatostatin. These results support the notion that age of onset may delineate subgroups of alcoholics with significant clinical and neurochemical differences.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalArchives of General Psychiatry
Volume48
Issue number5
DOIs
StatePublished - May 1991

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Roy, A., Dejong, J., Lamparski, D., Adinoff, B., George, T., Moore, V., Garnett, D., Kerich, M., & Linnoila, M. (1991). Mental Disorders Among Alcoholics: Relationship to Age of Onset and Cerebrospinal Fluid Neuropeptides. Archives of General Psychiatry, 48(5), 423-427. https://doi.org/10.1001/archpsyc.1991.01810290035006