Abstract
In adults, membranous nephropathy is the second most common cause of nephrotic syndrome. In contrast, minimal change disease and focal segmental glomerulosclerosis constitute the most common forms of nephrotic syndrome in children, while membranous nephropathy accounts for <5% of cases. In adults, causes of membranous nephropathy include autoantibodies directed against phospholipase A2 receptor and thrombospondin type 1 containing 7A, various infections, environmental toxicities, autoimmune disorders, malignancies, and other secondary forms. The most common causes of secondary membranous nephropathy in children are infections, autoimmune diseases, and neoplasia. We discuss an unusual presentation of new-onset membranous nephropathy due to mercury toxicity in a 14-year-old male with reflux nephropathy. This case underscores the importance of a high index of suspicion for uncommon causes of nephrotic syndrome in pediatric patients with membranous nephropathy.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Kidney Diseases |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- adolescent
- environmental exposure
- kidney biopsy
- kidney disease
- membranous nephropathy (MN)
- mercury
- mercury chelator
- Nephrotic syndrome
- pediatric nephrology
- poisoning
ASJC Scopus subject areas
- Nephrology
Cite this
Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child. / Onwuzuligbo, Oluwadamilola; Hendricks, Allen R.; Hassler, Jared; Domanski, Kristina; Goto, Collin; Wolf, Matthias T.F.
In: American Journal of Kidney Diseases, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child
AU - Onwuzuligbo, Oluwadamilola
AU - Hendricks, Allen R.
AU - Hassler, Jared
AU - Domanski, Kristina
AU - Goto, Collin
AU - Wolf, Matthias T.F.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In adults, membranous nephropathy is the second most common cause of nephrotic syndrome. In contrast, minimal change disease and focal segmental glomerulosclerosis constitute the most common forms of nephrotic syndrome in children, while membranous nephropathy accounts for <5% of cases. In adults, causes of membranous nephropathy include autoantibodies directed against phospholipase A2 receptor and thrombospondin type 1 containing 7A, various infections, environmental toxicities, autoimmune disorders, malignancies, and other secondary forms. The most common causes of secondary membranous nephropathy in children are infections, autoimmune diseases, and neoplasia. We discuss an unusual presentation of new-onset membranous nephropathy due to mercury toxicity in a 14-year-old male with reflux nephropathy. This case underscores the importance of a high index of suspicion for uncommon causes of nephrotic syndrome in pediatric patients with membranous nephropathy.
AB - In adults, membranous nephropathy is the second most common cause of nephrotic syndrome. In contrast, minimal change disease and focal segmental glomerulosclerosis constitute the most common forms of nephrotic syndrome in children, while membranous nephropathy accounts for <5% of cases. In adults, causes of membranous nephropathy include autoantibodies directed against phospholipase A2 receptor and thrombospondin type 1 containing 7A, various infections, environmental toxicities, autoimmune disorders, malignancies, and other secondary forms. The most common causes of secondary membranous nephropathy in children are infections, autoimmune diseases, and neoplasia. We discuss an unusual presentation of new-onset membranous nephropathy due to mercury toxicity in a 14-year-old male with reflux nephropathy. This case underscores the importance of a high index of suspicion for uncommon causes of nephrotic syndrome in pediatric patients with membranous nephropathy.
KW - adolescent
KW - environmental exposure
KW - kidney biopsy
KW - kidney disease
KW - membranous nephropathy (MN)
KW - mercury
KW - mercury chelator
KW - Nephrotic syndrome
KW - pediatric nephrology
KW - poisoning
UR - http://www.scopus.com/inward/record.url?scp=85050148881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050148881&partnerID=8YFLogxK
U2 - 10.1053/j.ajkd.2018.05.013
DO - 10.1053/j.ajkd.2018.05.013
M3 - Article
C2 - 30041877
AN - SCOPUS:85050148881
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
ER -