Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child

Oluwadamilola Onwuzuligbo, Allen R. Hendricks, Jared Hassler, Kristina Domanski, Collin Goto, Matthias T.F. Wolf

Research output: Contribution to journalArticle

Abstract

In adults, membranous nephropathy is the second most common cause of nephrotic syndrome. In contrast, minimal change disease and focal segmental glomerulosclerosis constitute the most common forms of nephrotic syndrome in children, while membranous nephropathy accounts for <5% of cases. In adults, causes of membranous nephropathy include autoantibodies directed against phospholipase A2 receptor and thrombospondin type 1 containing 7A, various infections, environmental toxicities, autoimmune disorders, malignancies, and other secondary forms. The most common causes of secondary membranous nephropathy in children are infections, autoimmune diseases, and neoplasia. We discuss an unusual presentation of new-onset membranous nephropathy due to mercury toxicity in a 14-year-old male with reflux nephropathy. This case underscores the importance of a high index of suspicion for uncommon causes of nephrotic syndrome in pediatric patients with membranous nephropathy.

Original languageEnglish (US)
JournalAmerican Journal of Kidney Diseases
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Membranous Glomerulonephritis
Mercury
Nephrotic Syndrome
Phospholipase A2 Receptors
Thrombospondin 1
Lipoid Nephrosis
Focal Segmental Glomerulosclerosis
Infection
Autoantibodies
Autoimmune Diseases
Neoplasms
Pediatrics

Keywords

  • adolescent
  • environmental exposure
  • kidney biopsy
  • kidney disease
  • membranous nephropathy (MN)
  • mercury
  • mercury chelator
  • Nephrotic syndrome
  • pediatric nephrology
  • poisoning

ASJC Scopus subject areas

  • Nephrology

Cite this

Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child. / Onwuzuligbo, Oluwadamilola; Hendricks, Allen R.; Hassler, Jared; Domanski, Kristina; Goto, Collin; Wolf, Matthias T.F.

In: American Journal of Kidney Diseases, 01.01.2018.

Research output: Contribution to journalArticle

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