Mesenchymal stem cells in hematopoietic stem cell transplantation

Peiman Hematti, Jaehyup Kim, Minoo Battiwalla

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Hematopoietic stem cell (HSC) transplantation, the only form of stem cell therapy in routine clinical practice, provides a curative option for treatment of a wide variety of malignant and non-malignant disorders. However, this potentially life-saving procedure is often associated with significant morbidity and mortality mainly due to graft versus host disease (GVHD). Mesenchymal stem cells (MSCs) are another type of stem cells present in bone marrow. These cells not only provide the supportive microenvironmental niche for hematopoietic stem cells but are also capable of differentiating into various cell types of mesenchymal origin, such as bone, fat, and cartilage. In vitro and in vivo data suggest that MSCs have low inherent immunogenicity, and modulate immunological responses through interactions with a wide range of innate and adaptive immune cells. MSCs participate in tissue regenerative processes through their diverse biological properties such as paracrine effects through growth factor and cytokine secretion. MSCs derived from bone marrow have been investigated extensively in the context of HSC transplantation, for promotion of engraftment, prevention of GVHD or treatment of GVHD or other complications associated with transplantation. Clinical studies of use of MSCs in HSC transplantation have paved the way for use of MSCs in a wide variety of other clinical indications.

Original languageEnglish (US)
Title of host publicationStem Cells and Human Diseases
PublisherSpringer Netherlands
Pages101-115
Number of pages15
ISBN (Electronic)9789400728011
ISBN (Print)940072800X, 9789400728004
DOIs
StatePublished - Apr 1 2014
Externally publishedYes

    Fingerprint

Keywords

  • Bone marrow transplant
  • Graft versus host disease
  • Hematopoietic stem cells
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hematti, P., Kim, J., & Battiwalla, M. (2014). Mesenchymal stem cells in hematopoietic stem cell transplantation. In Stem Cells and Human Diseases (pp. 101-115). Springer Netherlands. https://doi.org/10.1007/978-94-007-2801-1_5