Mesenchymal stem cells in hematopoietic stem cell transplantation

Peiman Hematti, Jaehyup Kim, Minoo Battiwalla

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hematopoietic stem cell (HSC) transplantation, the only form of stem cell therapy in routine clinical practice, provides a curative option for treatment of a wide variety of malignant and non-malignant disorders. However, this potentially life-saving procedure is often associated with significant morbidity and mortality mainly due to graft versus host disease (GVHD). Mesenchymal stem cells (MSCs) are another type of stem cells present in bone marrow. These cells not only provide the supportive microenvironmental niche for hematopoietic stem cells but are also capable of differentiating into various cell types of mesenchymal origin, such as bone, fat, and cartilage. In vitro and in vivo data suggest that MSCs have low inherent immunogenicity, and modulate immunological responses through interactions with a wide range of innate and adaptive immune cells. MSCs participate in tissue regenerative processes through their diverse biological properties such as paracrine effects through growth factor and cytokine secretion. MSCs derived from bone marrow have been investigated extensively in the context of HSC transplantation, for promotion of engraftment, prevention of GVHD or treatment of GVHD or other complications associated with transplantation. Clinical studies of use of MSCs in HSC transplantation have paved the way for use of MSCs in a wide variety of other clinical indications.

Original languageEnglish (US)
Title of host publicationStem Cells and Human Diseases
PublisherSpringer Netherlands
Pages101-115
Number of pages15
ISBN (Electronic)9789400728011
ISBN (Print)940072800X, 9789400728004
DOIs
StatePublished - Apr 1 2014
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Mesenchymal Stromal Cells
Graft vs Host Disease
Stem Cells
Bone Marrow
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
Cartilage
Intercellular Signaling Peptides and Proteins
Transplantation
Fats
Cytokines
Morbidity
Bone and Bones
Mortality
Therapeutics

Keywords

  • Bone marrow transplant
  • Graft versus host disease
  • Hematopoietic stem cells
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hematti, P., Kim, J., & Battiwalla, M. (2014). Mesenchymal stem cells in hematopoietic stem cell transplantation. In Stem Cells and Human Diseases (pp. 101-115). Springer Netherlands. https://doi.org/10.1007/978-94-007-2801-1_5

Mesenchymal stem cells in hematopoietic stem cell transplantation. / Hematti, Peiman; Kim, Jaehyup; Battiwalla, Minoo.

Stem Cells and Human Diseases. Springer Netherlands, 2014. p. 101-115.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hematti, P, Kim, J & Battiwalla, M 2014, Mesenchymal stem cells in hematopoietic stem cell transplantation. in Stem Cells and Human Diseases. Springer Netherlands, pp. 101-115. https://doi.org/10.1007/978-94-007-2801-1_5
Hematti P, Kim J, Battiwalla M. Mesenchymal stem cells in hematopoietic stem cell transplantation. In Stem Cells and Human Diseases. Springer Netherlands. 2014. p. 101-115 https://doi.org/10.1007/978-94-007-2801-1_5
Hematti, Peiman ; Kim, Jaehyup ; Battiwalla, Minoo. / Mesenchymal stem cells in hematopoietic stem cell transplantation. Stem Cells and Human Diseases. Springer Netherlands, 2014. pp. 101-115
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