Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function

Jiayi Xu, Traci M. Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W. Manichaikul, Fangui Sun, Natalie Terzikhan, Xia Zhou, Sarah L. Booth, Guy G. Brusselle, Ian H. De Boer, Myriam Fornage, Alexis C. Frazier-Wood, Mariaelisa Graff, Vilmundur Gudnason, Tamara B. Harris, Albert Hofman, Ruixue Hou, Denise K. Houston, David R. JacobsStephen B. Kritchevsky, Jeanne Latourelle, Rozenn N. Lemaitre, Pamela L. Lutsey, George O'Connor, Elizabeth C. Oelsner, James S. Pankow, Bruce M. Psaty, Rebecca R. Rohde, Stephen S. Rich, Jerome I. Rotter, Lewis J. Smith, Bruno H. Stricker, V. Saroja Voruganti, Thomas J. Wang, M. Carola Zillikens, R. Graham Barr, Josée Dupuis, Sina A. Gharib, Lies Lahousse, Stephanie J. London, Kari E. North, Albert V. Smith, Lyn M. Steffen, Dana B. Hancock, Patricia A. Cassano

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

Original languageEnglish (US)
Pages (from-to)1159-1170
Number of pages12
JournalBritish Journal of Nutrition
Volume120
Issue number10
DOIs
StatePublished - Nov 28 2018
Externally publishedYes

Keywords

  • African Americans
  • Forced expiratory volume
  • Respiratory function tests
  • Smoking
  • Vital capacity
  • Vitamin D
  • Whites

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function'. Together they form a unique fingerprint.

  • Cite this

    Xu, J., Bartz, T. M., Chittoor, G., Eiriksdottir, G., Manichaikul, A. W., Sun, F., Terzikhan, N., Zhou, X., Booth, S. L., Brusselle, G. G., De Boer, I. H., Fornage, M., Frazier-Wood, A. C., Graff, M., Gudnason, V., Harris, T. B., Hofman, A., Hou, R., Houston, D. K., ... Cassano, P. A. (2018). Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary function. British Journal of Nutrition, 120(10), 1159-1170. https://doi.org/10.1017/S0007114518002180