Meta-analysis of Usefulness of Phrenic Nerve Stimulation in Central Sleep Apnea

Faraz Khan Luni, James Daniels, Mark S. Link, Jose A. Joglar, Nath Zungsontiporn, Richard Wu, Neeraj Kaplish, Sonia Ali Malik

Research output: Contribution to journalArticle


Transvenous neurostimulation of the phrenic nerve (PNS) is a potentially improved and unique approach to the treatment of central sleep apnea (CSA). There have been multiple studies with limited individuals evaluating the efficacy of PNS. Our aim was to review and pool those studies to better understand whether phrenic nerve stimulation is efficacious in the treatment of CSA. The initial search on Pubmed retrieved a total of 97 articles and after screening all articles, only 5 could be included in our quantitative analysis. Pooling of data from 5 studies with a total of 204 patients demonstrated a reduction of mean apnea hypopnea index with PNS compared to controls by −26.7 events/hour with 95% confidence interval and P value of [CI (−31.99, −21.46), I2 85, p 0.00]. The mean difference in central apnea index was −22.47 [CI (−25.19, −19.76), I2 0, p 0.00]. The mean reduction in the oxygen desaturation index of 4% or more demonstrated a decrease in PNS group by −24.16 events/hour [(CI −26.20, −22.12), I2 0, p 0.00] compared with controls. PNS resulted in mean reduction in arousal index of −13.77 [CI (−16.15, −11.40), I2 0, p 0.00]. The mean change in percent of time spent in rapid eye movement sleep demonstrated a nonsignificant increase in PNS group by 1.01 % [CI (−5.67, 7.86), I293, p 0.75]. In conclusion, PNS therapy for treating CSA demonstrated positive outcomes but larger randomized studies are needed to evaluate the safety and clinical outcomes.

Original languageEnglish (US)
Pages (from-to)1738-1744
Number of pages7
JournalAmerican Journal of Cardiology
Issue number11
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Meta-analysis of Usefulness of Phrenic Nerve Stimulation in Central Sleep Apnea'. Together they form a unique fingerprint.

  • Cite this