Metabolic abnormality in the cerebellum in patients with essential tremor: A proton magnetic resonance spectroscopic imaging study

Elan D. Louis, Dikoma C. Shungu, Steven Chan, Xiangling Mao, Eva C. Jurewicz, Dryden Watner

Research output: Contribution to journalArticle

133 Scopus citations

Abstract

The pathological basis for essential tremor (ET) is unknown. We used proton magnetic resonance spectroscopic imaging (1H MRSI) in 16 ET patients and 11 controls to measure levels of intracellular metabolites, including N-acetyl-L-aspartate (NAA) and total choline, relative to total creatine (tCR), in several brain regions (cerebellum, thalamus, basal ganglia). Multislice 1H MRSI data were acquired on a 1.5 T GE Signa Scanner by prescribing four 15-mm axial-oblique slices. The mean (standard deviation) cerebellar cortical NAA/tCR was reduced in cases compared to controls (1.53 [0.36] versus 1.91 [0.49], P=0.03). There was an inverse association between cerebellar cortical NAA/tCR and dominant arm tremor severity (r=-0.59, P=0.02). The reduction in cerebellar cortical NAA/tCR indicates that there is neuronal damage or loss in ET, suggesting that ET may be a neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalNeuroscience letters
Volume333
Issue number1
DOIs
StatePublished - Nov 15 2002
Externally publishedYes

Keywords

  • Essential tremor
  • Magnetic resonance spectroscopic imaging
  • Metabolism
  • N-acetyl-L-aspartate
  • Neurodegenerative
  • Pathology

ASJC Scopus subject areas

  • Neuroscience(all)

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