Metabolic and Genetic Causes of Autism

Sailaja Golla; Patricia Evans

doi:10.1016/B978-0-12-410529-4.00019-X

Metabolic and Genetic Causes of Autism

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Most children with an autism diagnosis rarely have an etiology that can be identified as the cause for their behavior. However, there are well-described syndromes that are clearly associated with the development of the autistic phenotype. For children in whom no clear etiology can be found, the term idiopathic or primary autism is applicable. By contrast, those individuals whose autism is clearly a result of genetic or environmental causes are said to have a secondary autism. In this chapter, we provide a table that notes references specific to genomic regions most often associated with the autistic spectrum disorder (ASD) phenotype, followed by a brief discussion of several of the more well-known genetic causes for ASD.

Original language	English (US)
Title of host publication	Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
Subtitle of host publication	Fifth Edition
Publisher	Elsevier Inc.
Pages	209-217
Number of pages	9
ISBN (Electronic)	9780124105294
ISBN (Print)	9780124105492
DOIs	https://doi.org/10.1016/B978-0-12-410529-4.00019-X
State	Published - Nov 13 2014

Keywords

Angelman syndrome
Autistic spectrum disorder (ASD)
Chromosomal microarray (CMA)
Fragile X syndrome
In utero drug exposure
Neurocutaneous syndromes
Phenylketonuria
Rett syndrome
Second-hit theory
Smith-Lemli-Opitz syndrome

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-410529-4.00019-X

Cite this

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title = "Metabolic and Genetic Causes of Autism",

abstract = "Most children with an autism diagnosis rarely have an etiology that can be identified as the cause for their behavior. However, there are well-described syndromes that are clearly associated with the development of the autistic phenotype. For children in whom no clear etiology can be found, the term idiopathic or primary autism is applicable. By contrast, those individuals whose autism is clearly a result of genetic or environmental causes are said to have a secondary autism. In this chapter, we provide a table that notes references specific to genomic regions most often associated with the autistic spectrum disorder (ASD) phenotype, followed by a brief discussion of several of the more well-known genetic causes for ASD.",

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Metabolic and Genetic Causes of Autism

Abstract

Keywords

ASJC Scopus subject areas

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