TY - JOUR
T1 - Metabolic changes in the brain during transient ischemia measured with microdialysis
AU - Robertson, Claudia S.
AU - Gopinath, Shankar P.
AU - Uzura, Masahiko
AU - Valadka, Alex B.
AU - Goodman, J. Clay
PY - 1998
Y1 - 1998
N2 - Forty-four patients with severe head injury were monitored for episodes of cerebral ischemia using jugular venous oxygen saturation (sjvO2), brain tissue pO2 (ti-pO2), and a microdialysis probe. The concentration of lactate and glucose were measured in the microdialysate. A total of 10 episodes of global ischemia were observed. The characteristic pattern of a simultaneous decrease in sjvO2 and brain ti-pO2 with an increase in the concentration of lactate occurred in all 10 patients. In addition, 3 episodes of regional ischemia were observed. Although brain ti-pO2 decreased to very low values and the concentration of lactate increased in the microdialysate, sjvO2 remained unchanged. Brain ti-pO2 adds another dimension to our cerebral monitoring by allowing the detection of regional cerebral ischemia.
AB - Forty-four patients with severe head injury were monitored for episodes of cerebral ischemia using jugular venous oxygen saturation (sjvO2), brain tissue pO2 (ti-pO2), and a microdialysis probe. The concentration of lactate and glucose were measured in the microdialysate. A total of 10 episodes of global ischemia were observed. The characteristic pattern of a simultaneous decrease in sjvO2 and brain ti-pO2 with an increase in the concentration of lactate occurred in all 10 patients. In addition, 3 episodes of regional ischemia were observed. Although brain ti-pO2 decreased to very low values and the concentration of lactate increased in the microdialysate, sjvO2 remained unchanged. Brain ti-pO2 adds another dimension to our cerebral monitoring by allowing the detection of regional cerebral ischemia.
KW - Brain tissue pO
KW - Cerebral oxygenation
KW - Head injury
KW - Jugular venous oxygen saturation
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U2 - 10.1080/01616412.1998.11740618
DO - 10.1080/01616412.1998.11740618
M3 - Article
C2 - 9584933
AN - SCOPUS:0031900181
SN - 0161-6412
VL - 20
SP - S91-S94
JO - Neurological Research
JF - Neurological Research
IS - SUPPL. 1
ER -