Abstract
The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc− inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (PDK4) switches into a ferroptosis-resistant state in pancreatic cancer cells.
Original language | English (US) |
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Article number | 1901558 |
Journal | Molecular and Cellular Oncology |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - 2021 |
Keywords
- Ferroptosis
- fatty acid synthesis
- metabolic basis
- pancreatic cancer
- pyruvate oxidation
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research