Abstract
The metabolic clearance rate of dehydroisoandrosterone sulfate (MCRDS) was determined prospectively in gravidas with and without chronic essential hypertension. In normotensive patients, the MCRDS increased in a linear fashion throughout pregnancy. In patients with chronic essential hypertension the MCRDS also increased progressively, but at higher values than in normotensive subjects. In normotensive gravidas who ultimately developed pregnancy-induced hypertension, the MCRDS increased progressively at a higher level than in gravidas who remained normotensive until approximately 4 weeks prior to the onset of clinical symptoms, at which time the MCRDS slowly decreased. Similarly, in gravidas with chronic hypertension who developed superimposed pregnancy-induced hypertension, the MCRDS increased progressively at higher levels than all groups studied until approximately 4 weeks prior to the onset of hypertension, when a progressive decline in the MCRDS began.
Original language | English (US) |
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Pages (from-to) | 319-326 |
Number of pages | 8 |
Journal | Obstetrics and gynecology |
Volume | 47 |
Issue number | 3 |
State | Published - Mar 1976 |
ASJC Scopus subject areas
- Obstetrics and Gynecology