Metabolic clearance rate of dehydroisoandrosterone sulfate: V. studies of essential hypertension complicating pregnancy

N. F. Gant, J. D. Madden, S. Chand, R. J. Worley, J. D. Strong, P. C. MacDonald

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The metabolic clearance rate of dehydroisoandrosterone sulfate (MCRDS) was determined prospectively in gravidas with and without chronic essential hypertension. In normotensive patients, the MCRDS increased in a linear fashion throughout pregnancy. In patients with chronic essential hypertension the MCRDS also increased progressively, but at higher values than in normotensive subjects. In normotensive gravidas who ultimately developed pregnancy-induced hypertension, the MCRDS increased progressively at a higher level than in gravidas who remained normotensive until approximately 4 weeks prior to the onset of clinical symptoms, at which time the MCRDS slowly decreased. Similarly, in gravidas with chronic hypertension who developed superimposed pregnancy-induced hypertension, the MCRDS increased progressively at higher levels than all groups studied until approximately 4 weeks prior to the onset of hypertension, when a progressive decline in the MCRDS began.

Original languageEnglish (US)
Pages (from-to)319-326
Number of pages8
JournalObstetrics and gynecology
Volume47
Issue number3
StatePublished - Mar 1976

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Metabolic clearance rate of dehydroisoandrosterone sulfate: V. studies of essential hypertension complicating pregnancy'. Together they form a unique fingerprint.

  • Cite this

    Gant, N. F., Madden, J. D., Chand, S., Worley, R. J., Strong, J. D., & MacDonald, P. C. (1976). Metabolic clearance rate of dehydroisoandrosterone sulfate: V. studies of essential hypertension complicating pregnancy. Obstetrics and gynecology, 47(3), 319-326.